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Ivana Perkovic

Explore the profile of Ivana Perkovic including associated specialties, affiliations and a list of published articles. Areas
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Articles 27
Citations 177
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Recent Articles
1.
Penava A, Marinovic M, Pessanha de Carvalho L, Held J, Piantanida I, Saftic D, et al.
Molecules . 2025 Jan; 29(24. PMID: 39770079
As the resistance of to the existing antimalarials increases, there is a crucial need to expand the antimalarial drug pipeline. We recently identified potent antimalarial compounds, namely harmiquins, hybrids derived...
2.
Pavic K, Poje G, Pessanha de Carvalho L, Tandaric T, Marinovic M, Fontinha D, et al.
Bioorg Med Chem . 2024 Apr; 105:117734. PMID: 38677112
Although cancer and malaria are not etiologically nor pathophysiologically connected, due to their similarities successful repurposing of antimalarial drugs for cancer and vice-versa is known and used in clinical settings...
3.
Perkovic I, Poljak T, Savijoki K, Varmanen P, Maravic-Vlahovicek G, Beus M, et al.
Molecules . 2023 Aug; 28(15). PMID: 37570836
Inhibiting quorum sensing (QS), a central communication system, is a promising strategy to combat bacterial pathogens without antibiotics. Here, we designed novel hybrid compounds targeting the PQS ( quinolone signal)-dependent...
4.
Poje G, Marinovic M, Pavic K, Mioc M, Kralj M, Pessanha de Carvalho L, et al.
Int J Mol Sci . 2022 Aug; 23(16). PMID: 36012590
Cancer and malaria are both global health threats. Due to the increase in the resistance to the known drugs, research on new active substances is a priority. Here, we present...
5.
Poje G, Pessanha de Carvalho L, Held J, Moita D, Prudencio M, Perkovic I, et al.
Eur J Med Chem . 2022 May; 238:114408. PMID: 35551033
Malaria remains one of the major health problems worldwide. The lack of an effective vaccine and the increasing resistance of Plasmodium to the approved antimalarial drugs demands the development of...
6.
Vilibic-cavlek T, Stevanovic V, Brlek-Gorski D, Ferencak I, Ferenc T, Ujevic-Bosnjak M, et al.
Viruses . 2021 Dec; 13(12). PMID: 34960623
During the four pandemic waves, a total of 560,504 cases and 10,178 deaths due to COVID-19 were reported in Croatia. The Alpha variant, dominant from March 2021 (>50% of positive...
7.
Marinovic M, Poje G, Perkovic I, Fontinha D, Prudencio M, Held J, et al.
Eur J Med Chem . 2021 Jul; 224:113687. PMID: 34274829
The rise of the resistance of the malaria parasite to the currently approved therapy urges the discovery and development of new efficient agents. Previously we have demonstrated that harmicines, hybrid...
8.
Perkovic I, Beus M, Schols D, Persoons L, Zorc B
Mol Divers . 2020 Oct; 26(1):1-14. PMID: 33043404
In this paper, we report the synthesis of novel hybrids 2-14 based on itaconic acid and fluoroaniline, pyridine, indole and quinoline scaffolds. Itaconic acid is a naturally occurring compound with...
9.
Marinovic M, Perkovic I, Fontinha D, Prudencio M, Held J, Pessanha de Carvalho L, et al.
Molecules . 2020 Sep; 25(19). PMID: 32977642
Harmicines represent hybrid compounds composed of β-carboline alkaloid harmine and cinnamic acid derivatives (CADs). In this paper we report the synthesis of amide-type harmicines and the evaluation of their biological...
10.
Perkovic I, Raic-Malic S, Fontinha D, Prudencio M, Pessanha de Carvalho L, Held J, et al.
Eur J Med Chem . 2019 Dec; 187:111927. PMID: 31812035
Harmicines constitute novel hybrid compounds that combine two agents with reported antiplasmodial properties, namely β-carboline harmine and a cinnamic acid derivative (CAD). Cu(I) catalyzed azide-alkyne cycloaddition was employed for the...