Ittai Ben-Porath
Overview
Explore the profile of Ittai Ben-Porath including associated specialties, affiliations and a list of published articles.
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29
Citations
3891
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Recent Articles
11.
Grinshpun A, Gavert N, Granit R, Masuri H, Ben-Porath I, Breuer S, et al.
Cancer Biol Ther
. 2018 Mar;
19(8):645-648.
PMID: 29565707
The growing use of genomic testing presents new treatment options but also new dilemmas. We describe here a heavily-pretreated metastatic triple negative breast cancer patient who failed to respond to...
12.
Tarcic O, Granit R, Pateras I, Masury H, Maly B, Zwang Y, et al.
Cell Death Differ
. 2017 Feb;
24(4):694-704.
PMID: 28157208
Breast cancer subtypes display distinct biological traits that influence their clinical behavior and response to therapy. Recent studies have highlighted the importance of chromatin structure regulators in tumorigenesis. The RNF20-RNF40...
13.
Yosef R, Pilpel N, Tokarsky-Amiel R, Biran A, Ovadya Y, Cohen S, et al.
Nat Commun
. 2016 Apr;
7:11190.
PMID: 27048913
Senescent cells, formed in response to physiological and oncogenic stresses, facilitate protection from tumourigenesis and aid in tissue repair. However, accumulation of such cells in tissues contributes to age-related pathologies....
14.
Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, et al.
Nat Med
. 2016 Mar;
22(4):412-20.
PMID: 26950362
Cellular senescence is thought to contribute to age-associated deterioration of tissue physiology. The senescence effector p16(Ink4a) is expressed in pancreatic beta cells during aging and limits their proliferative potential; however,...
15.
Condiotti R, Guo W, Ben-Porath I
Crit Rev Oncog
. 2014 Nov;
19(5):337-48.
PMID: 25404149
Cellular heterogeneity is a prominent characteristic of breast cancers, and accumulating evidence indicates that variability in the differentiation state of tumor cells contributes to this phenomenon. Breast cancers are among...
16.
Strauss C, Kornowski M, Benvenisty A, Shahar A, Masury H, Ben-Porath I, et al.
Oncotarget
. 2014 Sep;
5(19):9396-409.
PMID: 25238049
Genomic instability, a hallmark of cancer, is commonly caused by failures in the DNA damage response. Here we conducted a bioinformatical screen to reveal DNA damage response genes that are...
17.
Granit R, Slyper M, Ben-Porath I
Wiley Interdiscip Rev Syst Biol Med
. 2014 Apr;
6(1):93-106.
PMID: 24741710
Differentiation-associated regulatory programs are central in determining tumor phenotype, and contribute to heterogeneity between tumors and between individual cells within them. The transcriptional programs that control luminal and basal lineage...
18.
Tokarsky-Amiel R, Azazmeh N, Helman A, Stein Y, Hassan A, Maly A, et al.
Cancer Res
. 2013 Feb;
73(9):2829-39.
PMID: 23423975
Cellular senescence, a state of cell-cycle arrest accompanied by dramatic morphologic and metabolic changes, is a central means by which cells respond to physiologic stress and oncogene activity. Senescence is...
19.
Sebban S, Farago M, Gashai D, Ilan L, Pikarsky E, Ben-Porath I, et al.
PLoS One
. 2013 Jan;
8(1):e54321.
PMID: 23342133
Vav1 functions as a signal transducer protein in the hematopoietic system, where it is exclusively expressed. Vav1 was recently implicated in several human cancers, including lung, pancreatic and neuroblasoma. In...
20.
Control of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3
Slyper M, Shahar A, Bar-Ziv A, Granit R, Hamburger T, Maly B, et al.
Cancer Res
. 2012 Oct;
72(21):5613-24.
PMID: 23090119
Regulatory factors controlling stem cell identity and self-renewal are often active in aggressive cancers and are thought to promote their growth and progression. TCF3 (also known as TCF7L1) is a...