Stimulation of Epidermal Hyperplasia and Tumorigenesis by Resident P16-expressing Cells
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Abstract
p16 (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16 in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16 in early epidermal lesions, which could potentially be targeted by senolytic therapy.
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Fairfield H, Costa S, Falank C, Farrell M, Murphy C, DAmico A Front Oncol. 2021; 10:584683.
PMID: 33680918 PMC: 7930573. DOI: 10.3389/fonc.2020.584683.
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