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Ismael Gonzalez-Garcia

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Articles 39
Citations 931
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Recent Articles
1.
Ouro A, Rodriguez-Diaz A, Lopez-Gonzalez T, Romaus-Sanjurjo D, Estevez-Salguero A, Iglesias-Rey R, et al.
Metabolism . 2025 Feb; 167:156160. PMID: 39961478
Background And Aims: Smoking is a known risk factor for stroke. However, the 'stroke paradox' refers to the observation that stroke patients who smoke often have higher survival rates and...
2.
Freire-Agulleiro O, Estevez-Salguero A, Ferreira V, Holleman C, Garcia-Curras J, Gonzalez-Garcia I, et al.
Mol Metab . 2025 Jan; 92:102091. PMID: 39746605
Objective: AMP-activated protein kinase (AMPK) is a heterotrimer complex consisting of a catalytic α subunit (α1, α2) with a serine/threonine kinase domain, and two regulatory subunits, β (β1, β2) and...
3.
da Silva Lima N, Cabaleiro A, Novoa E, Riobello C, Knerr P, He Y, et al.
Cell Mol Life Sci . 2024 Nov; 81(1):468. PMID: 39607493
The use of incretin agonists for managing metabolic dysfunction-associated steatohepatitis (MASH) is currently experiencing considerable interest. However, whether these compounds have a direct action on MASH is still under debate....
4.
Contreras R, Gruber T, Gonzalez-Garcia I, Schriever S, De Angelis M, Mallet N, et al.
Mol Metab . 2024 Sep; 90:102033. PMID: 39304061
With age, metabolic perturbations accumulate to elevate our obesity burden. While age-onset obesity is mostly driven by a sedentary lifestyle and high calorie intake, genetic and epigenetic factors also play...
5.
Lopez M, Dieguez C, Tena-Sempere M, Gonzalez-Garcia I
Trends Endocrinol Metab . 2024 Jul; 36(1):11-14. PMID: 38972782
Central ceramides regulate energy metabolism by impacting hypothalamic neurons. This allows ceramides to integrate endocrine signals - such as leptin, ghrelin, thyroid hormones, or estradiol - and to modulate the...
6.
Luengo-Mateos M, Gonzalez-Vila A, Torres Caldas A, Alasaoufi A, Gonzalez-Dominguez M, Lopez M, et al.
STAR Protoc . 2024 Feb; 5(1):102910. PMID: 38416648
Ovariectomy, involving the surgical removal of ovaries, and estradiol replacement facilitate the understanding of sexual dimorphism-related physiological changes, encompassing reproductive biology, metabolism, and hormone-related diseases. In this study, we present...
7.
Dragano N, Milbank E, Haddad-Tovolli R, Garrido-Gil P, Novoa E, Fondevilla M, et al.
Mol Metab . 2023 Nov; 79:101840. PMID: 38036170
Objective: Free fatty acid receptor-1 (FFAR1) is a medium- and long-chain fatty acid sensing G protein-coupled receptor that is highly expressed in the hypothalamus. Here, we investigated the central role...
8.
Gruber T, Lechner F, Murat C, Contreras R, Sanchez-Quant E, Miok V, et al.
Cell Rep . 2023 Oct; 42(10):113305. PMID: 37864798
Oxytocin-expressing paraventricular hypothalamic neurons (PVN neurons) integrate afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy homeostasis. However, the molecular underpinnings by which PVN neurons orchestrate gut-to-brain...
9.
Gonzalez-Garcia I, Garcia-Caceres C
Nat Metab . 2023 Aug; 5(9):1454-1455. PMID: 37653042
No abstract available.
10.
Gonzalez-Garcia I, Lopez M
Trends Pharmacol Sci . 2023 Jul; 44(9):635-636. PMID: 37423792
No abstract available.