Ishrut Hussain
Overview
Explore the profile of Ishrut Hussain including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
30
Citations
698
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Dimitrov M, Alattia J, Lemmin T, Lehal R, Fligier A, Houacine J, et al.
Nat Commun
. 2013 Aug;
4:2246.
PMID: 23907250
Pathological amino-acid substitutions in the amyloid precursor protein (APP) and chemical γ-secretase modulators affect the processing of APP by the γ-secretase complex and the production of the amyloid-beta peptide Aβ42,...
2.
Huang Y, Li T, Eatherton A, Mitchell W, Rong N, Ye L, et al.
Neuropharmacology
. 2013 Mar;
70:278-86.
PMID: 23485401
Accumulation of amyloid β (Aβ) in brain is a pathological hallmark of Alzheimer's disease (AD). Aβ is generated after sequential cleavage of its parental molecule, amyloid precursor protein (APP), by...
3.
Dassie E, Andrews M, Bensadoun J, Cacquevel M, Schneider B, Aebischer P, et al.
Neurobiol Aging
. 2013 Jan;
34(5):1355-68.
PMID: 23273572
Adeno-associated virus serotype 6 (AAV6) viral vectors encoding mutant and normal tau were used to produce focal tau pathology. Two mutant forms of tau were used; the P301S tau mutation...
4.
Ousson S, Saric A, Baguet A, Losberger C, Genoud S, Vilbois F, et al.
J Neurochem
. 2012 Dec;
125(4):610-9.
PMID: 23253155
The molecular mechanisms governing γ-secretase cleavage specificity are not fully understood. Herein, we demonstrate that extending the transmembrane domain of the amyloid precursor protein-derived C99 substrate in proximity to the...
5.
Hussain I, Fabregue J, Anderes L, Ousson S, Borlat F, Eligert V, et al.
J Biol Chem
. 2012 Dec;
288(4):2521-31.
PMID: 23209290
γ-Secretase is a large enzyme complex comprising presenilin, nicastrin, presenilin enhancer 2, and anterior pharynx-defective 1 that mediates the intramembrane proteolysis of a large number of proteins including amyloid precursor...
6.
Saric A, Brugge L, Muller-Pompalla D, Rysiok T, Ousson S, Permanne B, et al.
J Biomol Screen
. 2012 Oct;
18(3):277-85.
PMID: 23023105
β-Site amyloid precursor protein cleaving enzyme-1 (BACE-1) is a transmembrane aspartic protease that mediates the initial cleavage of the amyloid precursor protein (APP), leading to the generation of amyloid-β (Aβ)...
7.
Waters K, Stean T, Hammond B, Virley D, Upton N, Kew J, et al.
Behav Brain Res
. 2011 Dec;
228(1):211-8.
PMID: 22189656
The 5-hydroxytryptamine7 (5-HT7) receptor is a G-protein coupled receptor for serotonin that has been implicated in the pathophysiology of psychiatric and neurological disorders including anxiety, depression and schizophrenia. A number...
8.
Li T, Huang Y, Jin S, Ye L, Rong N, Yang X, et al.
J Neurochem
. 2011 Nov;
121(2):277-86.
PMID: 22035227
γ-secretase inhibitors (GSIs) have been developed to reduce amyloid-β (Aβ) production for the treatment of Alzheimer's disease by inhibiting the cleavage of amyloid precursor protein (APP). However, cross-inhibitory activity on...
9.
Meakin P, Harper A, Hamilton D, Gallagher J, McNeilly A, Burgess L, et al.
Biochem J
. 2011 Sep;
441(1):285-96.
PMID: 21880018
Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease). An essential feature of AD pathology is the...
10.
Wan Z, Hall A, Sang Y, Xiang J, Yang E, Smith B, et al.
Bioorg Med Chem Lett
. 2011 Jul;
21(16):4832-5.
PMID: 21742495
SAR of a novel series of pyridine-derived γ-secretase modulators is described. Compound 5 was found to be a potent modulator in vitro, which on further profiling, was found to decrease...