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Iseki Takamoto

Explore the profile of Iseki Takamoto including associated specialties, affiliations and a list of published articles. Areas
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Articles 40
Citations 2759
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Recent Articles
1.
Arakawa N, Aoyama T, Suwanai H, Toda G, Takamoto I, Okazaki Y, et al.
J Diabetes Investig . 2024 Dec; PMID: 39714319
Aims: Diabetic chorea refers to sudden involuntary movements developing in people with diabetes mellitus and is known to occur mainly in those with severe hyperglycemia. We conducted a questionnaire survey...
2.
Sakurai Y, Kubota N, Takamoto I, Wada N, Aihara M, Hayashi T, et al.
Diabetes . 2023 Dec; 73(3):474-489. PMID: 38064504
Genome-wide association studies have identified several gene polymorphisms, including UBE2E2, associated with type 2 diabetes. Although UBE2E2 is one of the ubiquitin-conjugating enzymes involved in the process of ubiquitin modifications,...
3.
Takeuchi T, Kubota T, Nakanishi Y, Tsugawa H, Suda W, Kwon A, et al.
Nature . 2023 Aug; 621(7978):389-395. PMID: 37648852
Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes. Previous metagenomic studies have described the characteristics of gut microbiota and their roles in metabolizing major nutrients...
4.
Iso H, Cui R, Takamoto I, Kiyama M, Saito I, Okamura T, et al.
J Am Heart Assoc . 2021 Nov; 10(23):e020760. PMID: 34796738
Background It is uncertain whether risk classification under the nationwide program on screening and lifestyle modification for metabolic syndrome captures well high-risk individuals who could benefit from lifestyle interventions. We...
5.
Hayashi T, Kubota T, Mariko I, Takamoto I, Aihara M, Sakurai Y, et al.
Diabetes . 2021 May; 70(8):1640-1653. PMID: 33980693
Insulin receptor substrate-1 (Irs1) is one of the major substrates for insulin receptor and insulin-like growth factor-1 (IGF-1) receptor tyrosine kinases. Systemic Irs1-deficient mice show growth retardation, with resistance to...
6.
Aihara M, Kubota N, Minami T, Shirakawa R, Sakurai Y, Hayashi T, et al.
J Diabetes Investig . 2020 Jul; 12(2):266-276. PMID: 32621777
Aims/introduction: To prevent diabetic complications, strict glucose control and frequent monitoring of blood glucose levels with invasive methods are necessary. We considered the monitoring of tear glucose levels might be...
7.
Kubota T, Inoue M, Kubota N, Takamoto I, Mineyama T, Iwayama K, et al.
Nat Commun . 2018 Nov; 9(1):4863. PMID: 30451856
M2a-subtype macrophage activation is known to be impaired in obesity, although the underlying mechanisms remain poorly understood. Herein, we demonstrate that, the IL-4/Irs2/Akt pathway is selectively impaired, along with decreased...
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Abe-Doi M, Oe M, Murayama R, Takahashi M, Zushi Y, Tanabe H, et al.
Diabetes Technol Ther . 2017 Oct; 19(11):651-659. PMID: 29024607
Background: Performing self-monitoring of blood glucose (SMBG) is a clinical challenge for elderly people with low dexterity. An all-in-one-type SMBG device that can simply and easily puncture and monitor would...
10.
Sakurai Y, Kubota N, Takamoto I, Obata A, Iwamoto M, Hayashi T, et al.
Sci Rep . 2017 Jul; 7(1):5387. PMID: 28710407
Several cellular signaling pathways, including insulin/IGF signaling, are known to be activated in hepatocellular carcinoma (HCC). Here, we investigated the roles of insulin receptor substrate (Irs) 1 and Irs2, both...