Iseki Takamoto
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Explore the profile of Iseki Takamoto including associated specialties, affiliations and a list of published articles.
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40
Citations
2759
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Recent Articles
11.
Sasaki M, Sasako T, Kubota N, Sakurai Y, Takamoto I, Kubota T, et al.
Diabetes
. 2017 Jun;
66(9):2339-2350.
PMID: 28630133
Growing attention has been focused on the roles of the proximal tubules (PTs) of the kidney in glucose metabolism, including the mechanism of regulation of gluconeogenesis. In this study, we...
12.
Masamoto Y, Arai S, Sato T, Kubota N, Takamoto I, Kadowaki T, et al.
Stem Cells
. 2017 May;
35(7):1835-1848.
PMID: 28480607
Myelotoxic injury, such as chemotherapeutic agents and ionizing radiation, unlocks the vigorous power of hematopoietic stem cells (HSCs) to replenish the hematopoietic system, making quiescent HSCs enter the cell cycle....
13.
Fujiwara T, Takamoto I, Amemiya A, Hanazato M, Suzuki N, Nagamine Y, et al.
Soc Sci Med
. 2017 Apr;
182:45-51.
PMID: 28412640
Background: Although living in a hilly environment may promote muscular activity in the daily lives of residents, and such activity may prevent diabetes mellitus, few studies have focused on the...
14.
Kubota N, Kubota T, Kajiwara E, Iwamura T, Kumagai H, Watanabe T, et al.
Nat Commun
. 2016 Oct;
7:12977.
PMID: 27708333
Hepatic insulin signalling involves insulin receptor substrates (Irs) 1/2, and is normally associated with the inhibition of gluconeogenesis and activation of lipogenesis. In diabetes and obesity, insulin no longer suppresses...
15.
Kubota T, Kubota N, Sato H, Inoue M, Kumagai H, Iwamura T, et al.
Sci Rep
. 2016 Oct;
6:34707.
PMID: 27703271
The aim of this study is to elucidate to what degree adiponectin is involved in TZD-mediated amelioration of neointimal formation. We investigated the effect of 3- or 8-weeks' pioglitazone on...
16.
Sato H, Kubota N, Kubota T, Takamoto I, Iwayama K, Tokuyama K, et al.
Diabetologia
. 2016 Aug;
59(11):2426-2434.
PMID: 27525648
Aims/hypothesis: Recently, incretin-related agents have been reported to attenuate insulin resistance in animal models, although the underlying mechanisms remain unclear. In this study, we investigated whether anagliptin, the dipeptidyl peptidase...
17.
Masamoto Y, Arai S, Sato T, Yoshimi A, Kubota N, Takamoto I, et al.
Immunity
. 2016 Jun;
44(6):1422-33.
PMID: 27317261
Obesity has been shown to increase the morbidity of infections, however, the underlying mechanisms remain largely unknown. Here we demonstrate that obesity caused adiponectin deficiency in the bone marrow (BM),...
18.
Obata A, Kubota N, Kubota T, Iwamoto M, Sato H, Sakurai Y, et al.
Endocrinology
. 2015 Dec;
157(3):1029-42.
PMID: 26713783
Sodium glucose cotransporter 2 inhibitors have attracted attention as they exert antidiabetic and antiobesity effects. In this study, we investigated the effects of tofogliflozin on glucose homeostasis and its metabolic...
19.
Nakatsu D, Horiuchi Y, Kano F, Noguchi Y, Sugawara T, Takamoto I, et al.
Proc Natl Acad Sci U S A
. 2015 Feb;
112(10):E1067-76.
PMID: 25713368
Increase in the concentration of plasma L-cysteine is closely associated with defective insulin secretion from pancreatic β-cells, which results in type 2 diabetes (T2D). In this study, we investigated the...
20.
Hashimoto S, Kubota N, Sato H, Sasaki M, Takamoto I, Kubota T, et al.
Diabetes
. 2014 Oct;
64(3):876-86.
PMID: 25277391
Endothelial cells are considered to be essential for normal pancreatic β-cell function. The current study attempted to demonstrate the role of insulin receptor substrate-2 (Irs2) in endothelial cells with regard...