Isabelle Hmitou
Overview
Explore the profile of Isabelle Hmitou including associated specialties, affiliations and a list of published articles.
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9
Citations
282
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0
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Recent Articles
1.
Delville M, Touzot F, Couzin C, Hmitou I, Djerroudi L, Ouedrani A, et al.
Mol Ther Methods Clin Dev
. 2019 Mar;
13:303-309.
PMID: 30911587
Although the risk of developing lymphoma has decreased in the highly active antiretroviral therapy era, this cancer remains the major cause of mortality in HIV-infected patients. Autologous hematopoietic stem cell...
2.
Berlivet S, Hmitou I, Picaud H, Gerard M
Methods Mol Biol
. 2017 Jul;
1622:91-100.
PMID: 28674803
The development of the CRISPR/Cas9 technology has provided powerful methods to target genetic alterations. However, investigating the function of genes essential for cell survival remains problematic, because genetic ablation of...
3.
Gabrion A, Hmitou I, Moshous D, Neven B, Lefevre-Utile A, Diana J, et al.
J Allergy Clin Immunol
. 2016 Oct;
139(5):1641-1649.e6.
PMID: 27702670
Background: Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defective production of reactive oxygen species in phagocytic cells that results in life-threatening infections and severe inflammatory manifestations. The...
4.
de Dieuleveult M, Yen K, Hmitou I, Depaux A, Boussouar F, Bou Dargham D, et al.
Nature
. 2016 Jan;
530(7588):113-6.
PMID: 26814966
ATP-dependent chromatin remodellers allow access to DNA for transcription factors and the general transcription machinery, but whether mammalian chromatin remodellers target specific nucleosomes to regulate transcription is unclear. Here we...
5.
Valluet A, Hmitou I, Davis S, Druillennec S, Larcher M, Laroche S, et al.
PLoS One
. 2011 Jan;
5(12):e15272.
PMID: 21203559
The B-raf proto-oncogene exerts essential functions during development and adulthood. It is required for various processes, such as placental development, postnatal nervous system myelination and adult learning and memory. The...
6.
Coste I, Le Corf K, Kfoury A, Hmitou I, Druillennec S, Hainaut P, et al.
J Clin Invest
. 2010 Oct;
120(10):3663-7.
PMID: 20941850
Accumulating evidence points to inflammation as a promoter of carcinogenesis. MyD88 is an adaptor molecule in TLR and IL-1R signaling that was recently implicated in tumorigenesis through proinflammatory mechanisms. Here...
7.
Metrich M, Laurent A, Breckler M, Duquesnes N, Hmitou I, Courillau D, et al.
Cell Signal
. 2010 Jun;
22(10):1459-68.
PMID: 20576488
Epac (Exchange protein directly activated by cAMP) is a sensor for cAMP and represents a novel mechanism for governing cAMP signalling. Epac is a guanine nucleotide exchange factor (GEF) for...
8.
Lezoualch F, Metrich M, Hmitou I, Duquesnes N, Morel E
J Mol Cell Cardiol
. 2008 Mar;
44(4):623-32.
PMID: 18339399
Small GTP-binding proteins (small G proteins) act as GDP-GTP-regulated molecular switches and are activated by guanine nucleotide exchange factors (GEFs) in response to diverse extracellular stimuli. During this last decade,...
9.
Hmitou I, Druillennec S, Valluet A, Peyssonnaux C, Eychene A
Mol Cell Biol
. 2006 Nov;
27(1):31-43.
PMID: 17074813
The B-Raf proto-oncogene encodes several isoforms resulting from alternative splicing in the hinge region upstream of the kinase domain. The presence of exon 8b in the B2-Raf(8b) isoform and exon...