Isabelle Coppens
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Explore the profile of Isabelle Coppens including associated specialties, affiliations and a list of published articles.
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149
Citations
10581
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Recent Articles
21.
Won T, Wood M, Hughes D, Talor M, Ma Z, Schneider J, et al.
EBioMedicine
. 2022 Jan;
75:103812.
PMID: 35033854
Background: Thromboembolism is a life-threatening manifestation of coronavirus disease 2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells in the lungs during COVID-19. Methods: We obtained the lung...
22.
Jensen B, Vaney P, Flaspohler J, Coppens I, Parsons M
PLoS One
. 2021 Oct;
16(10):e0258814.
PMID: 34653230
In many eukaryotes, multiple protein kinases are situated in the plasma membrane where they respond to extracellular ligands. Ligand binding elicits a signal that is transmitted across the membrane, leading...
23.
Li Z, King T, Ayong L, Asady B, Cai X, Rahman T, et al.
Nat Commun
. 2021 Oct;
12(1):5802.
PMID: 34608145
Two-pore channels (TPCs) are a ubiquitous family of cation channels that localize to acidic organelles in animals and plants to regulate numerous Ca-dependent events. Little is known about TPCs in...
24.
Romano J, Hartman E, Coppens I
Methods Mol Biol
. 2021 Aug;
2293:295-305.
PMID: 34453726
Fluorescence microscopy and image analysis are powerful techniques to examine the distribution and interactions of different cellular compartments, including mammalian organelles with intravacuolar pathogens. Toxoplasma gondii is an obligate intracellular...
25.
Sahu T, Gehrke E, Flores-Garcia Y, Mlambo G, Romano J, Coppens I
NPJ Vaccines
. 2021 Aug;
6(1):98.
PMID: 34376691
Genetically attenuated sporozoite vaccines can elicit long-lasting protection against malaria but pose risks of breakthrough infection. Chemoprophylaxis vaccination (CVac) has proven to be the most effective vaccine strategy against malaria....
26.
Gubbels M, Coppens I, Zarringhalam K, Duraisingh M, Engelberg K
Front Cell Infect Microbiol
. 2021 Apr;
11:670049.
PMID: 33912479
The close-knit group of apicomplexan parasites displays a wide variety of cell division modes, which differ between parasites as well as between different life stages within a single parasite species....
27.
Smith D, Kannan G, Coppens I, Wang F, Mai Nguyen H, Cerutti A, et al.
Elife
. 2021 Apr;
10.
PMID: 33904393
Many of the world's warm-blooded species are chronically infected with tissue cysts, including an estimated one-third of the global human population. The cellular processes that permit long-term persistence within the...
28.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
29.
Asady B, Dick C, Ehrenman K, Sahu T, Romano J, Coppens I
PLoS Pathog
. 2020 Dec;
16(12):e1009067.
PMID: 33383579
Inorganic ions such as phosphate, are essential nutrients required for a broad spectrum of cellular functions and regulation. During infection, pathogens must obtain inorganic phosphate (Pi) from the host. Despite...
30.
Desai R, East D, Hardy L, Faccenda D, Rigon M, Crosby J, et al.
Sci Adv
. 2020 Dec;
6(51).
PMID: 33355129
Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as mitochondrial retrograde response (MRR) and is induced by mitochondrial dysfunction. MRR results in the...