Isabelle Bougie
Overview
Explore the profile of Isabelle Bougie including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
292
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Recent Articles
1.
Issur M, Bougie I, Despins S, Bisaillon M
PLoS One
. 2013 Oct;
8(9):e75310.
PMID: 24086504
RNA cap binding proteins have evolved to specifically bind to the N7-methyl guanosine cap structure found at the 5' ends of eukaryotic mRNAs. The specificity of RNA capping enzymes towards...
2.
The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme
Picard-Jean F, Bougie I, Shuto S, Bisaillon M
PLoS One
. 2013 Jan;
8(1):e54621.
PMID: 23349942
Mizoribine monophosphate (MZP) is a specific inhibitor of the cellular inosine-5'-monophosphate dehydrogenase (IMPDH), the enzyme catalyzing the rate-limiting step of de novo guanine nucleotide biosynthesis. MZP is a highly potent...
3.
Tremblay-Letourneau M, Despins S, Bougie I, Bisaillon M
PLoS One
. 2011 Sep;
6(9):e24806.
PMID: 21935470
The RNA guanylyltransferase (GTase) is involved in the synthesis of the (m7)Gppp-RNA cap structure found at the 5' end of eukaryotic mRNAs. GTases are members of the covalent nucleotidyl transferase...
4.
Despins S, Issur M, Bougie I, Bisaillon M
Nucleic Acids Res
. 2010 Apr;
38(16):5493-506.
PMID: 20421212
The West Nile virus RNA helicase uses the energy derived from the hydrolysis of nucleotides to separate complementary strands of RNA. Although this enzyme has a preference for ATP, the...
5.
Issur M, Geiss B, Bougie I, Picard-Jean F, Despins S, Mayette J, et al.
RNA
. 2009 Oct;
15(12):2340-50.
PMID: 19850911
The 5'-end of the flavivirus genome harbors a methylated (m7)GpppA(2'OMe) cap structure, which is generated by the virus-encoded RNA triphosphatase, RNA (guanine-N7) methyltransferase, nucleoside 2'-O-methyltransferase, and RNA guanylyltransferase. The presence...
6.
Issur M, Despins S, Bougie I, Bisaillon M
Nucleic Acids Res
. 2009 Apr;
37(11):3714-22.
PMID: 19372271
RNA triphosphatases (RTPases) are involved in the addition of the distinctive cap structure found at the 5' ends of eukaryotic mRNAs. Fungi, protozoa and some DNA viruses possess an RTPase...
7.
Bougie I, Bisaillon M
Biochim Biophys Acta
. 2008 Oct;
1794(1):50-60.
PMID: 18930844
West Nile virus (WNV) is a member of the Flaviviridae family which includes a number of important human pathogens. The WNV NS5 protein harbors an RNA-dependent RNA polymerase activity which...
8.
Picard-Jean F, Bougie I, Bisaillon M
Biochem J
. 2007 Aug;
407(3):331-41.
PMID: 17672827
The catalytic subunit of the human cytomegalovirus DNA polymerase is critical for the replication of the virus. In the present study, we report the expression and purification of a recombinant...
9.
Bougie I, Bisaillon M
Yeast
. 2007 Apr;
24(5):431-46.
PMID: 17410550
The 3' ends of eukaryotic mRNAs are characterized by the presence of a poly(A) tail, which plays a critical role in stability, transport, and translation of the mRNAs. In the...
10.
Bougie I, Bisaillon M
Biochem J
. 2006 Jun;
398(3):557-67.
PMID: 16761952
Paramecium bursaria chlorella virus, a large DNA virus that replicates in unicellular Chlorella-like algae, encodes an RNA triphosphatase which is involved in the synthesis of the RNA cap structure found...