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» Authors » Moheshwarnath Issur

Moheshwarnath Issur

Explore the profile of Moheshwarnath Issur including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 193
Followers 0
Related Specialties
Biochemistry
Microbiology
General Medicine
Top 10 Co-Authors
Martin Bisaillon
Simon Despins
Isabelle Bougie
Matthias Gotte
Frederic Picard-Jean
Mamuka Kvaratskhelia
Sarah E Hobdey
Brian J Geiss
Hsiao-Wei Liu
Marianne Ngure
Published In
Nucleic Acids Res
PLoS One
RNA
Viruses
Wiley Interdiscip Rev RNA
Affiliations
Soon will be listed here.
Recent Articles
1.
Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap
Ngure M, Issur M, Shkriabai N, Liu H, Cosa G, Kvaratskhelia M, et al.
ACS Infect Dis . 2016 Sep; 2(11):839-851. PMID: 27676132
Domain II of the nonstructural protein 5 (NS5A) of the hepatitis C virus (HCV) is involved in intermolecular interactions with the viral RNA genome, the RNA-dependent RNA polymerase NS5B, and...
2.
Resistance patterns associated with HCV NS5A inhibitors provide limited insight into drug binding
Issur M, Gotte M
Viruses . 2014 Nov; 6(11):4227-41. PMID: 25384189
Direct-acting antivirals (DAAs) have significantly improved the treatment of infection with the hepatitis C virus. A promising class of novel antiviral agents targets the HCV NS5A protein. The high potency...
3.
Enzymatic synthesis of RNAs capped with nucleotide analogues reveals the molecular basis for substrate selectivity of RNA capping enzyme: impacts on RNA metabolism
Issur M, Bougie I, Despins S, Bisaillon M
PLoS One . 2013 Oct; 8(9):e75310. PMID: 24086504
RNA cap binding proteins have evolved to specifically bind to the N7-methyl guanosine cap structure found at the 5' ends of eukaryotic mRNAs. The specificity of RNA capping enzymes towards...
4.
The RNA capping machinery as an anti-infective target
Issur M, Picard-Jean F, Bisaillon M
Wiley Interdiscip Rev RNA . 2011 Sep; 2(2):184-92. PMID: 21957005
A number of different human pathogens code for their own enzymes involved in the synthesis of the RNA cap structure. Although the RNA cap structures originating from human and microbial...
5.
Deciphering the molecular basis for nucleotide selection by the West Nile virus RNA helicase
Despins S, Issur M, Bougie I, Bisaillon M
Nucleic Acids Res . 2010 Apr; 38(16):5493-506. PMID: 20421212
The West Nile virus RNA helicase uses the energy derived from the hydrolysis of nucleotides to separate complementary strands of RNA. Although this enzyme has a preference for ATP, the...
6.
The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure
Issur M, Geiss B, Bougie I, Picard-Jean F, Despins S, Mayette J, et al.
RNA . 2009 Oct; 15(12):2340-50. PMID: 19850911
The 5'-end of the flavivirus genome harbors a methylated (m7)GpppA(2'OMe) cap structure, which is generated by the virus-encoded RNA triphosphatase, RNA (guanine-N7) methyltransferase, nucleoside 2'-O-methyltransferase, and RNA guanylyltransferase. The presence...
7.
Nucleotide analogs and molecular modeling studies reveal key interactions involved in substrate recognition by the yeast RNA triphosphatase
Issur M, Despins S, Bougie I, Bisaillon M
Nucleic Acids Res . 2009 Apr; 37(11):3714-22. PMID: 19372271
RNA triphosphatases (RTPases) are involved in the addition of the distinctive cap structure found at the 5' ends of eukaryotic mRNAs. Fungi, protozoa and some DNA viruses possess an RTPase...