Irwin Bernstein
Overview
Explore the profile of Irwin Bernstein including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
589
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Recent Articles
1.
Freie B, Carroll P, Varnum-Finney B, Ramsey E, Ramani V, Bernstein I, et al.
Genes Dev
. 2024 Apr;
38(5-6):253-272.
PMID: 38565249
Oncogenic activation of MYC in cancers predominantly involves increased transcription rather than coding region mutations. However, MYC-dependent lymphomas frequently acquire point mutations in the MYC phosphodegron, including at threonine 58...
2.
Freie B, Carroll P, Varnum-Finney B, Ramani V, Bernstein I, Eisenman R
bioRxiv
. 2023 Nov;
PMID: 37961183
Oncogenic activation of MYC in cancers predominantly involves increased transcription rather than coding region mutations. However, MYC-dependent lymphomas frequently contain point mutations in the MYC phospho-degron, including at threonine-58 (T58),...
3.
Kaonis S, Smith J, Katiyar N, Merrill M, Hyelkma T, Namciu S, et al.
bioRxiv
. 2023 Sep;
PMID: 37693371
Oncogenic fusions involving transcription factors are present in the majority of pediatric leukemias; however, the context-specific mechanisms they employ to drive cancer remain poorly understood. CBFA2T3-GLIS2 (C/G) fusions occur in...
4.
Le Q, Hadland B, Meshinchi S, Bernstein I
Leukemia
. 2020 Jun;
35(2):601-605.
PMID: 32513964
No abstract available.
5.
Tarlock K, Alonzo T, Wang Y, Gerbing R, Ries R, Loken M, et al.
Clin Cancer Res
. 2019 Jun;
25(16):5038-5048.
PMID: 31182436
Purpose: mutations ( ) are common in core binding factor (CBF) AML and have been associated with varying prognostic significance. We sought to define the functional and clinical significance of...
6.
Lux C, Pattabhi S, Berger M, Nourigat C, Flowers D, Negre O, et al.
Mol Ther Methods Clin Dev
. 2019 Feb;
12:175-183.
PMID: 30705922
Elements within the γ-hemoglobin promoters ( and ) function to bind transcription complexes that mediate repression of fetal hemoglobin expression. Sickle cell disease (SCD) subjects with a 13-bp deletion in...
7.
Palpant N, Wang Y, Hadland B, Zaunbrecher R, Redd M, Jones D, et al.
Cell Rep
. 2017 Aug;
20(7):1597-1608.
PMID: 28813672
We analyzed chromatin dynamics and transcriptional activity of human embryonic stem cell (hESC)-derived cardiac progenitor cells (CPCs) and KDR/CD34 endothelial cells generated from different mesodermal origins. Using an unbiased algorithm...
8.
Ganuza M, Hadland B, Chabot A, Li C, Guolian Kang , Bernstein I, et al.
Exp Hematol
. 2017 Apr;
51:25-35.e6.
PMID: 28450163
Hematopoietic stem and progenitor cells (HSPCs) sustain life-long hematopoiesis and are first detected in the embryo by transplantation at embryonic day 10.5 (E10.5). HSPCs are mesodermal in origin and ultimately...
9.
Palpant N, Pabon L, Friedman C, Roberts M, Hadland B, Zaunbrecher R, et al.
Nat Protoc
. 2016 Dec;
12(1):15-31.
PMID: 27906170
Human pluripotent stem cells (hPSCs) provide a valuable model for the study of human development and a means to generate a scalable source of cells for therapeutic applications. This protocol...
10.
Wang J, Wegener J, Huang T, Sripathy S, De Jesus-Cortes H, Xu P, et al.
Nature
. 2015 Jul;
525(7570):552.
PMID: 26176914
No abstract available.