Irtisha Singh
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Explore the profile of Irtisha Singh including associated specialties, affiliations and a list of published articles.
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25
Citations
711
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Recent Articles
11.
Brokesh A, Cross L, Kersey A, Murali A, Richter C, Gregory C, et al.
Sci Adv
. 2022 Apr;
8(17):eabl9404.
PMID: 35476448
Bioactive materials harness the body's innate regenerative potential by directing endogenous progenitor cells to facilitate tissue repair. Dissolution products of inorganic biomaterials provide unique biomolecular signaling for tissue-specific differentiation. Inorganic...
12.
Arabzade A, Zhao Y, Varadharajan S, Chen H, Jessa S, Rivas B, et al.
Cancer Discov
. 2021 Mar;
11(9):2200-2215.
PMID: 33741710
More than 60% of supratentorial ependymomas harbor a (ZR) gene fusion (formerly ). To study the biology of ZR, we developed an autochthonous mouse tumor model using electroporation (IUE) of...
13.
Carrow J, Singh K, Jaiswal M, Ramirez A, Lokhande G, Yeh A, et al.
Proc Natl Acad Sci U S A
. 2020 May;
117(24):13329-13338.
PMID: 32461372
Two-dimensional (2D) molybdenum disulfide (MoS) nanomaterials are an emerging class of biomaterials that are photoresponsive at near-infrared wavelengths (NIR). Here, we demonstrate the ability of 2D MoS to modulate cellular...
14.
Chimene D, Miller L, Cross L, Jaiswal M, Singh I, Gaharwar A
ACS Appl Mater Interfaces
. 2020 Feb;
12(14):15976-15988.
PMID: 32091189
Bioprinting is an emerging additive manufacturing approach to the fabrication of patient-specific, implantable three-dimensional (3D) constructs for regenerative medicine. However, developing cell-compatible bioinks with high printability, structural stability, biodegradability, and...
15.
Sin-Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, et al.
Cancer Cell
. 2019 Jul;
36(1):51-67.e7.
PMID: 31287992
Embryonal tumors with multilayered rosettes (ETMRs) are highly lethal infant brain cancers with characteristic amplification of Chr19q13.41 miRNA cluster (C19MC) and enrichment of pluripotency factor LIN28A. Here we investigated C19MC...
16.
Mack S, Singh I, Wang X, Hirsch R, Wu Q, Villagomez R, et al.
J Exp Med
. 2019 Apr;
216(5):1071-1090.
PMID: 30948495
Glioblastoma is an incurable brain cancer characterized by high genetic and pathological heterogeneity. Here, we mapped active chromatin landscapes with gene expression, whole exomes, copy number profiles, and DNA methylomes...
17.
Fulciniti M, Lin C, Samur M, Lopez M, Singh I, Lawlor M, et al.
Cell Rep
. 2018 Dec;
25(13):3693-3705.e6.
PMID: 30590042
The relationship between promoter proximal transcription factor-associated gene expression and super-enhancer-driven transcriptional programs are not well defined. However, their distinct genomic occupancy suggests a mechanism for specific and separable gene...
18.
Lee S, Singh I, Tisdale S, Abdel-Wahab O, Leslie C, Mayr C
Nature
. 2018 Aug;
561(7721):127-131.
PMID: 30150773
DNA mutations are known cancer drivers. Here we investigated whether mRNA events that are upregulated in cancer can functionally mimic the outcome of genetic alterations. RNA sequencing or 3'-end sequencing...
19.
Singh I, Lee S, Sperling A, Samur M, Tai Y, Fulciniti M, et al.
Nat Commun
. 2018 May;
9(1):1716.
PMID: 29712909
Alternative cleavage and polyadenylation (ApA) is known to alter untranslated region (3'UTR) length but can also recognize intronic polyadenylation (IpA) signals to generate transcripts that lose part or all of...
20.
Carrow J, Cross L, Reese R, Jaiswal M, Gregory C, Kaunas R, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(17):E3905-E3913.
PMID: 29643075
Two-dimensional nanomaterials, an ultrathin class of materials such as graphene, nanoclays, transition metal dichalcogenides (TMDs), and transition metal oxides (TMOs), have emerged as a new generation of materials due to...