Irina Proekt
Overview
Explore the profile of Irina Proekt including associated specialties, affiliations and a list of published articles.
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14
Citations
527
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Recent Articles
1.
Nielsen H, Yang L, Mueller J, Ritter A, Hiwa R, Proekt I, et al.
Nat Commun
. 2025 Jan;
16(1):784.
PMID: 39824797
The Nr4a nuclear hormone receptors are transcriptionally upregulated in response to antigen recognition by the T cell receptor (TCR) in the thymus and are implicated in clonal deletion, but the...
2.
Rackaityte E, Proekt I, Miller H, Ramesh A, Brooks J, Kung A, et al.
JCI Insight
. 2023 Nov;
8(23).
PMID: 37934865
Autoimmunity is characterized by loss of tolerance to tissue-specific as well as systemic antigens, resulting in complex autoantibody landscapes. Here, we introduce and extensively validate the performance characteristics of a...
3.
Sin J, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, et al.
Sci Immunol
. 2023 Oct;
8(88):eabq3109.
PMID: 37889983
Mutations in the gene encoding the zinc-finger transcription factor Ikaros () are found in patients with immunodeficiency, leukemia, and autoimmunity. Although Ikaros has a well-established function in modulating gene expression...
4.
Rackaityte E, Proekt I, Miller H, Ramesh A, Brooks J, Kung A, et al.
bioRxiv
. 2023 Apr;
PMID: 37066405
Autoimmunity is characterized by loss of tolerance to tissue-specific as well as systemic antigens, resulting in complex autoantibody landscapes. Here, we introduce and extensively validate the performance characteristics of a...
5.
Vazquez S, Mann S, Bodansky A, Kung A, Quandt Z, Ferre E, et al.
Elife
. 2022 Oct;
11.
PMID: 36300623
Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understood forms of...
6.
Owen D, Mahmud S, Sjaastad L, Williams J, Spanier J, Simeonov D, et al.
Nat Immunol
. 2019 Jan;
20(2):195-205.
PMID: 30643267
The developmental programs that generate a broad repertoire of regulatory T cells (T cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that...
7.
Miller C, Proekt I, von Moltke J, Wells K, Rajpurkar A, Wang H, et al.
Nature
. 2018 Jul;
559(7715):627-631.
PMID: 30022164
The thymus is responsible for generating a diverse yet self-tolerant pool of T cells. Although the thymic medulla consists mostly of developing and mature AIRE epithelial cells, recent evidence has...
8.
Proekt I, Miller C, Lionakis M, Anderson M
Curr Opin Immunol
. 2017 Oct;
49:71-78.
PMID: 29065385
AIRE is a well-established master regulator of central tolerance. It plays an essential role in driving expression of tissue-specific antigens in the thymus and shaping the development of positively selected...
9.
LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity
Proekt I, Miller C, Jeanne M, Fasano K, Moon J, Lowell C, et al.
J Clin Invest
. 2016 Aug;
126(10):3758-3771.
PMID: 27571405
Studies of the genetic factors associated with human autoimmune disease suggest a multigenic origin of susceptibility; however, how these factors interact and through which tolerance pathways they operate generally remain...
10.
LaFlam T, Seumois G, Miller C, Lwin W, Fasano K, Waterfield M, et al.
J Exp Med
. 2015 Nov;
212(12):1993-2002.
PMID: 26527800
Thymic central tolerance is essential to preventing autoimmunity. In medullary thymic epithelial cells (mTECs), the Autoimmune regulator (Aire) gene plays an essential role in this process by driving the expression...