Irina A Leaf
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Explore the profile of Irina A Leaf including associated specialties, affiliations and a list of published articles.
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9
Citations
1870
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Recent Articles
1.
Puranik A, Leaf I, Jensen M, Hedayat A, Saad A, Kim K, et al.
Sci Rep
. 2018 Sep;
8(1):13948.
PMID: 30224726
Renal artery stenosis (RAS) caused by narrowing of arteries is characterized by microvascular damage. Macrophages are implicated in repair and injury, but the specific populations responsible for these divergent roles...
2.
Lemos D, McMurdo M, Karaca G, Wilflingseder J, Leaf I, Gupta N, et al.
J Am Soc Nephrol
. 2018 May;
29(6):1690-1705.
PMID: 29739813
Kidney injury is characterized by persisting inflammation and fibrosis, yet mechanisms by which inflammatory signals drive fibrogenesis remain poorly defined. RNA sequencing of fibrotic kidneys from patients with CKD identified...
3.
Leaf I, Duffield J
Nephrol Dial Transplant
. 2017 Apr;
32(suppl_1):i89-i97.
PMID: 28391346
Fibrosis, a characteristic of all chronic kidney diseases, is now recognized to be an independent predictor of disease progression. Deposition of pathological matrix in the walls of glomerular capillaries, the...
4.
Leaf I, Nakagawa S, Johnson B, Cha J, Mittelsteadt K, Guckian K, et al.
J Clin Invest
. 2016 Nov;
127(1):321-334.
PMID: 27869651
Fibrotic disease is associated with matrix deposition that results in the loss of organ function. Pericytes, the precursors of myofibroblasts, are a source of pathological matrix collagens and may be...
5.
Aachoui Y, Kajiwara Y, Leaf I, Mao D, Ting J, Coers J, et al.
Cell Host Microbe
. 2015 Sep;
18(3):320-32.
PMID: 26320999
The inflammatory caspases 1 and 11 are activated in response to different agonists and act independently to induce pyroptosis. In the context of IL-1β/IL-18 secretion, however, in vitro studies indicate...
6.
Aachoui Y, Leaf I, Hagar J, Fontana M, Campos C, Zak D, et al.
Science
. 2013 Jan;
339(6122):975-8.
PMID: 23348507
Caspases are either apoptotic or inflammatory. Among inflammatory caspases, caspase-1 and -11 trigger pyroptosis, a form of programmed cell death. Whereas both can be detrimental in inflammatory disease, only caspase-1...
7.
Miao E, Leaf I, Treuting P, Mao D, Dors M, Sarkar A, et al.
Nat Immunol
. 2010 Nov;
11(12):1136-42.
PMID: 21057511
Macrophages mediate crucial innate immune responses via caspase-1-dependent processing and secretion of interleukin 1β (IL-1β) and IL-18. Although infection with wild-type Salmonella typhimurium is lethal to mice, we show here...
8.
Warren S, Armstrong A, Hamilton M, Mao D, Leaf I, Miao E, et al.
J Immunol
. 2010 Jun;
185(2):818-21.
PMID: 20562263
Pathogens are detected by pattern recognition receptors that, upon activation, orchestrate an appropriate immune response. The TLRs and the nucleotide-binding oligomerization domain-like receptors (NLRs) are prototypic pattern recognition receptors that...
9.
Miao E, Mao D, Yudkovsky N, Bonneau R, Lorang C, Warren S, et al.
Proc Natl Acad Sci U S A
. 2010 Feb;
107(7):3076-80.
PMID: 20133635
The mammalian innate immune system uses Toll-like receptors (TLRs) and Nod-LRRs (NLRs) to detect microbial components during infection. Often these molecules work in concert; for example, the TLRs can stimulate...