Iolanda Micco
Overview
Explore the profile of Iolanda Micco including associated specialties, affiliations and a list of published articles.
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11
Citations
93
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Recent Articles
1.
Petersen L, Christensen A, Andersen J, Folkesson C, Kristensen O, Andersen C, et al.
J Am Chem Soc
. 2021 Feb;
143(7):2751-2756.
PMID: 33577316
DNA-encoded small molecule libraries (DELs) have facilitated the discovery of novel modulators of many different therapeutic protein targets. We report the first successful screening of a multimillion membered DEL inside...
2.
Madsen D, Azevedo C, Micco I, Petersen L, Hansen N
Prog Med Chem
. 2020 May;
59:181-249.
PMID: 32362328
DNA-encoded libraries (DELs) are collections of small molecules covalently attached to amplifiable DNA tags carrying unique information about the structure of each library member. A combinatorial approach is used to...
3.
Zaytsev A, Dodd B, Magnani M, Ghiron C, Golding B, Griffin R, et al.
Chem Biol Drug Des
. 2014 Nov;
86(2):180-9.
PMID: 25388787
Two libraries of substituted benzimidazoles were designed using a 'scaffold-hopping' approach based on reported MDM2-p53 inhibitors. Substituents were chosen following library enumeration and docking into an MDM2 X-ray structure. Benzimidazole...
4.
Nencini A, Castaldo C, Comery T, Dunlop J, Genesio E, Ghiron C, et al.
Eur J Med Chem
. 2014 Apr;
78:401-18.
PMID: 24704613
α7 nicotinic acetylcholine receptor agonists are promising therapeutic candidates for the treatment of cognitive impairment. As a follow up of our internal medicinal chemistry program we investigated a novel series...
5.
Zanaletti R, Bettinetti L, Castaldo C, Ceccarelli I, Cocconcelli G, Comery T, et al.
J Med Chem
. 2012 Oct;
55(22):10277-81.
PMID: 23083093
α7 Nicotinic acetylcholine receptors (α7 nAChR) represent promising therapeutic candidates for the treatment of cognitive impairment associated with Alzheimer's disease (AD) and schizophrenia. A medicinal chemistry effort around previously reported...
6.
Benicchi T, Iozzi S, Svahn A, Axelsson H, Mori E, Bernocco S, et al.
J Biomol Screen
. 2012 May;
17(7):933-45.
PMID: 22644269
The TWEAK-Fn14 pathway is upregulated in models of inflammation, autoimmune diseases, and cancer. Both TWEAK and Fn14 show increased expression also in the CNS in response to different stimuli, particularly...
7.
Zanaletti R, Bettinetti L, Castaldo C, Cocconcelli G, Comery T, Dunlop J, et al.
J Med Chem
. 2012 Apr;
55(10):4806-23.
PMID: 22468936
Alpha-7 nicotinic acetylcholine receptors (α7 nAChR) are implicated in the modulation of many cognitive functions such as attention, working memory, and episodic memory. For this reason, α7 nAChR agonists represent...
8.
Ghiron C, Haydar S, Aschmies S, Bothmann H, Castaldo C, Cocconcelli G, et al.
J Med Chem
. 2010 May;
53(11):4379-89.
PMID: 20465311
Alpha-7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment. We report a series of novel, potent small molecule agonists (4-18) of the...
9.
Haydar S, Ghiron C, Bettinetti L, Bothmann H, Comery T, Dunlop J, et al.
Bioorg Med Chem
. 2009 Jun;
17(14):5247-58.
PMID: 19515567
Alpha 7 nicotinic acetylcholine receptor (alpha(7) nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment associated with a variety of disorders including Alzheimer's disease and schizophrenia. Alpha...
10.
Micco I, Nencini A, Quinn J, Bothmann H, Ghiron C, Padova A, et al.
Bioorg Med Chem
. 2007 Dec;
16(5):2313-28.
PMID: 18078760
Alpha7 agonists were identified via GOLD (CCDC) docking in the putative agonist binding site of an alpha7 homology model and a series of aminoalkyl benzoimidazoles was synthesised to obtain potentially...