Ioannis I Verginadis
Overview
Explore the profile of Ioannis I Verginadis including associated specialties, affiliations and a list of published articles.
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41
Citations
936
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Recent Articles
1.
Kazerooni A, Akbari H, Hu X, Bommineni V, Grigoriadis D, Toorens E, et al.
Commun Med (Lond)
. 2025 Mar;
5(1):55.
PMID: 40025245
Background: Glioblastoma is a highly heterogeneous brain tumor, posing challenges for precision therapies and patient stratification in clinical trials. Understanding how genetic mutations influence tumor imaging may improve patient management...
2.
Verginadis I, Velalopoulou A, Kim M, Kim K, Paraskevaidis I, Bell B, et al.
Radiother Oncol
. 2025 Jan;
205:110744.
PMID: 39880309
Background And Purpose: The normal tissue sparing afforded by FLASH radiotherapy is being intensely investigated for potential clinical translation. Here, we studied the effects of FLASH proton radiotherapy (F-PRT) in...
3.
Verginadis I, Citrin D, Ky B, Feigenberg S, Georgakilas A, Hill-Kayser C, et al.
Lancet
. 2025 Jan;
405(10475):338-352.
PMID: 39827884
For over a century, radiotherapy has revolutionised cancer treatment. Technological advancements aim to deliver high doses to tumours with increased precision while minimising off-target effects to organs at risk. Despite...
4.
Lim T, Morral C, Verginadis I, Kim K, Luo L, Foley C, et al.
bioRxiv
. 2024 Sep;
PMID: 39229237
Ultra-high dose rate ("FLASH") radiotherapy (>40-60 Gy/s) is a promising new radiation modality currently in human clinical trials. Previous studies showed that FLASH proton radiotherapy (FR) improves toxicity of normal...
5.
Amit U, Uslu U, Verginadis I, Kim M, Oliaei Motlagh S, Diffenderfer E, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(31):e2403002121.
PMID: 39047033
Pancreatic ductal adenocarcinoma (PDAC) represents a challenge in oncology, with limited treatment options for advanced-stage patients. Chimeric antigen receptor T cell (CAR T) therapy targeting mesothelin (MSLN) shows promise, but...
6.
Verginadis I, Velalopoulou A, Kim M, Kim K, Paraskevaidis I, Bell B, et al.
bioRxiv
. 2024 Jul;
PMID: 39026805
Background And Purpose: The normal tissue sparing afforded by FLASH radiotherapy (RT) is being intensely investigated for potential clinical translation. Here, we studied the effects of FLASH proton RT (F-PRT)...
7.
Loo Jr B, Verginadis I, Sorensen B, Mascia A, Perentesis J, Koong A, et al.
Semin Radiat Oncol
. 2024 Jun;
34(3):351-364.
PMID: 38880544
The "FLASH effect" is an increased therapeutic index, that is, reduced normal tissue toxicity for a given degree of anti-cancer efficacy, produced by ultra-rapid irradiation delivered on time scales orders...
8.
Logotheti S, Pavlopoulou A, Rudsari H, Galow A, Kafali Y, Kyrodimos E, et al.
Pharmacol Ther
. 2024 Jun;
260:108670.
PMID: 38823489
Advances in cancer therapeutics have improved patient survival rates. However, cancer survivors may suffer from adverse events either at the time of therapy or later in life. Cardiovascular diseases (CVD)...
9.
Chowdhury P, Velalopoulou A, Verginadis I, Morcos G, Loo P, Kim M, et al.
Mol Cancer Ther
. 2024 Apr;
23(6):877-889.
PMID: 38593239
Head and neck cancer radiotherapy often damages salivary glands and oral mucosa, severely negatively impacting patients' quality of life. The ability of FLASH proton radiotherapy (F-PRT) to decrease normal tissue...
10.
Morral C, Ayyaz A, Kuo H, Fink M, Verginadis I, Daniel A, et al.
Nat Commun
. 2024 Apr;
15(1):3018.
PMID: 38589357
Ionizing radiation induces cell death in the gastrointestinal (GI) epithelium by activating p53. However, p53 also prevents animal lethality caused by radiation-induced acute GI syndrome. Through single-cell RNA-sequencing of the...