Eric S Diffenderfer
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Explore the profile of Eric S Diffenderfer including associated specialties, affiliations and a list of published articles.
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34
Citations
496
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Recent Articles
1.
Ni H, Reitman Z, Zou W, Akhtar M, Paul R, Huang M, et al.
Nat Cancer
. 2025 Feb;
PMID: 39910249
FLASH radiotherapy holds promise for treating solid tumors given the potential lower toxicity in normal tissues but its therapeutic effects on tumor immunity remain largely unknown. Using a genetically engineered...
2.
Verginadis I, Velalopoulou A, Kim M, Kim K, Paraskevaidis I, Bell B, et al.
Radiother Oncol
. 2025 Jan;
205:110744.
PMID: 39880309
Background And Purpose: The normal tissue sparing afforded by FLASH radiotherapy is being intensely investigated for potential clinical translation. Here, we studied the effects of FLASH proton radiotherapy (F-PRT) in...
3.
Chhabra A, Amos R, Simone 2nd C, Simone C, Kaiser A, Perles L, et al.
Int J Radiat Oncol Biol Phys
. 2025 Jan;
PMID: 39761799
Radiation therapy manages pancreatic cancer in various settings; however, the proximity of gastrointestinal (GI) luminal organs at risk (OARs) poses challenges to conventional radiation therapy. Proton beam therapy (PBT) may...
4.
Georgescu A, Oved J, Galarraga J, Cantrell T, Mehta S, Dulmovits B, et al.
Cell Stem Cell
. 2024 Dec;
31(12):1847-1864.e6.
PMID: 39642865
Here, we present a bioengineering approach to emulate the human bone marrow in vitro. Our developmentally inspired method uses self-organization of human hematopoietic stem and progenitor cells and vascular endothelial...
5.
Amit U, Uslu U, Verginadis I, Kim M, Oliaei Motlagh S, Diffenderfer E, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(31):e2403002121.
PMID: 39047033
Pancreatic ductal adenocarcinoma (PDAC) represents a challenge in oncology, with limited treatment options for advanced-stage patients. Chimeric antigen receptor T cell (CAR T) therapy targeting mesothelin (MSLN) shows promise, but...
6.
Verginadis I, Velalopoulou A, Kim M, Kim K, Paraskevaidis I, Bell B, et al.
bioRxiv
. 2024 Jul;
PMID: 39026805
Background And Purpose: The normal tissue sparing afforded by FLASH radiotherapy (RT) is being intensely investigated for potential clinical translation. Here, we studied the effects of FLASH proton RT (F-PRT)...
7.
Chowdhury P, Velalopoulou A, Verginadis I, Morcos G, Loo P, Kim M, et al.
Mol Cancer Ther
. 2024 Apr;
23(6):877-889.
PMID: 38593239
Head and neck cancer radiotherapy often damages salivary glands and oral mucosa, severely negatively impacting patients' quality of life. The ability of FLASH proton radiotherapy (F-PRT) to decrease normal tissue...
8.
Cengel K, Kim M, Diffenderfer E, Busch T
Semin Radiat Oncol
. 2024 Mar;
34(2):218-228.
PMID: 38508786
FLASH is an emerging treatment paradigm in radiotherapy (RT) that utilizes ultra-high dose rates (UHDR; >40 Gy)/s) of radiation delivery. Developing advances in technology support the delivery of UHDR using...
9.
Kim K, Kim M, Skoufos G, Diffenderfer E, Oliaei Motlagh S, Kokkorakis M, et al.
Int J Radiat Oncol Biol Phys
. 2024 Feb;
119(4):1234-1247.
PMID: 38364948
Purpose: Studies during the past 9 years suggest that delivering radiation at dose rates exceeding 40 Gy/s, known as "FLASH" radiation therapy, enhances the therapeutic index of radiation therapy (RT)...
10.
Rotolo A, Whelan E, Atherton M, Kulikovskaya I, Jarocha D, Fraietta J, et al.
Cell Rep Med
. 2023 Oct;
4(10):101241.
PMID: 37852175
Allogeneic invariant natural killer T cells (allo-iNKTs) induce clinical remission in patients with otherwise incurable cancers and COVID-19-related acute respiratory failure. However, their functionality is inconsistent among individuals, and they...