Ileana M Cristea
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Explore the profile of Ileana M Cristea including associated specialties, affiliations and a list of published articles.
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181
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8119
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Recent Articles
11.
Cristea I, Eyers C
J Proteome Res
. 2024 Aug;
23(8):2675-2679.
PMID: 39091215
No abstract available.
12.
Liu D, Yang J, Cristea I
Trends Immunol
. 2024 May;
45(6):454-469.
PMID: 38762334
Intrinsic and innate immune responses are essential lines of defense in the body's constant surveillance of pathogens. The discovery of liquid-liquid phase separation (LLPS) as a key regulator of this...
13.
Liu X, Abad L, Chatterjee L, Cristea I, Varjosalo M
Mass Spectrom Rev
. 2024 May;
PMID: 38742660
Protein-protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and...
14.
Justice J, Reed T, Phelan B, Greco T, Hutton J, Cristea I
Cell Syst
. 2024 Apr;
15(4):339-361.e8.
PMID: 38593799
The DNA-dependent protein kinase, DNA-PK, is an essential regulator of DNA damage repair. DNA-PK-driven phosphorylation events and the activated DNA damage response (DDR) pathways are also components of antiviral intrinsic...
15.
Lum K, Reed T, Yang J, Cristea I
J Proteome Res
. 2024 Apr;
23(8):3249-3268.
PMID: 38564653
Fundamental to mammalian intrinsic and innate immune defenses against pathogens is the production of Type I and Type II interferons, such as IFN-β and IFN-γ, respectively. The comparative effects of...
16.
Hofstadter W, Tsopurashvili E, Cristea I
PLoS Biol
. 2024 Mar;
22(3):e3002529.
PMID: 38442090
At the core of organelle functions lies their ability and need to form dynamic organelle-organelle networks that drive intracellular communication and coordination of cellular pathways. These networks are facilitated by...
17.
Reed T, Tyl M, Tadych A, Troyanskaya O, Cristea I
Nat Methods
. 2024 Feb;
21(3):488-500.
PMID: 38361019
Protein-protein interactions (PPIs) drive cellular processes and responses to environmental cues, reflecting the cellular state. Here we develop Tapioca, an ensemble machine learning framework for studying global PPIs in dynamic...
18.
Kichuk T, Dhamankar S, Malani S, Hofstadter W, Wegner S, Cristea I, et al.
Cell Rep Methods
. 2024 Jan;
4(1):100692.
PMID: 38232737
We have developed an open-source workflow that allows for quantitative single-cell analysis of organelle morphology, distribution, and inter-organelle contacts with an emphasis on the analysis of mitochondria and mitochondria-endoplasmic reticulum...
19.
Omenn G, Lane L, Overall C, Lindskog C, Pineau C, Packer N, et al.
J Proteome Res
. 2024 Jan;
23(2):532-549.
PMID: 38232391
Since 2010, the Human Proteome Project (HPP), the flagship initiative of the Human Proteome Organization (HUPO), has pursued two goals: (1) to credibly identify the protein parts list and (2)...
20.
Betsinger C, Justice J, Tyl M, Edgar J, Budayeva H, Abu Y, et al.
mSystems
. 2023 Nov;
8(6):e0051023.
PMID: 37916830
This study expands the growing understanding that protein acetylation is a highly regulated molecular toggle of protein function in both host anti-viral defense and viral replication. We describe a pro-viral...