Michael P Rout
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Explore the profile of Michael P Rout including associated specialties, affiliations and a list of published articles.
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155
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7799
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Recent Articles
1.
Fung H, Mittal S, Niesman A, Jiou J, Shakya B, Yoshizawa T, et al.
Nat Commun
. 2025 Mar;
16(1):2580.
PMID: 40089503
Gene expression in response to environmental stimuli is dependent on nuclear localization of key signaling components, which can be tightly regulated by phosphorylation. This is exemplified by the phosphate-sensing transcription...
2.
Ge T, Brickner D, Zehr K, VanBelzen D, Zhang W, Caffalette C, et al.
Mol Cell
. 2025 Mar;
PMID: 40068679
Nuclear pore proteins (nucleoporins [Nups]) physically interact with hundreds of chromosomal sites, impacting transcription. In yeast, transcription factors mediate interactions between Nups and enhancers and promoters. To define the molecular...
3.
Ketaren N, Fridy P, Malashkevich V, Sanyal T, Brillantes M, Thompson M, et al.
Structure
. 2025 Feb;
PMID: 39938509
Nanobodies are single domain antibody variants proving themselves to be compelling tools for research, disease diagnostics, and as therapeutics targeting a myriad of disease agents. However, despite this potential, their...
4.
Fridy P, Rout M, Ketaren N
Mol Cell Proteomics
. 2024 Oct;
23(12):100865.
PMID: 39433212
The camelid single-domain antibody fragment, commonly referred to as a nanobody, achieves the targeting power of conventional monoclonal antibodies (mAbs) at only a fraction of their size. Isolated from camelid...
5.
Fung H, Mittal S, Niesman A, Jiou J, Shakya B, Yoshizawa T, et al.
bioRxiv
. 2024 Aug;
PMID: 39211127
Gene expression in response to environmental stimuli is dependent on nuclear localization of key signaling components, which can be tightly regulated by phosphorylation. This is exemplified by the phosphate-sensing transcription...
6.
Singh D, Soni N, Hutchings J, Echeverria I, Shaikh F, Duquette M, et al.
Cell
. 2024 Aug;
187(19):5267-5281.e13.
PMID: 39127037
The nuclear pore complex (NPC) is the sole mediator of nucleocytoplasmic transport. Despite great advances in understanding its conserved core architecture, the peripheral regions can exhibit considerable variation within and...
7.
A new generation of nanobody research tools using improved mass spectrometry-based discovery methods
Fridy P, Farrell R, Molloy K, Keegan S, Wang J, Jacobs E, et al.
J Biol Chem
. 2024 Aug;
300(9):107623.
PMID: 39098531
Single-domain antibodies ("nanobodies") derived from the variable region of camelid heavy-chain only antibody variants have proven to be widely useful tools for research, therapeutic, and diagnostic applications. In addition to...
8.
Hernandez C, Duran-Chaparro D, van Eeuwen T, Rout M, Holt L
bioRxiv
. 2024 Jul;
PMID: 39005449
The mechanisms that regulate the physical properties of the cell interior remain poorly understood, especially at the mesoscale (10nm-100nm). Changes in these properties have been suggested to be crucial for...
9.
Ge T, Brickner D, Zehr K, VanBelzen D, Zhang W, Caffalette C, et al.
bioRxiv
. 2024 May;
PMID: 38798450
Nuclear pore proteins (Nups) in yeast, flies and mammals physically interact with hundreds or thousands of chromosomal sites, which impacts transcriptional regulation. In budding yeast, transcription factors mediate interaction of...
10.
Ketaren N, Mast F, Fridy P, Olivier J, Sanyal T, Sali A, et al.
Elife
. 2024 May;
12.
PMID: 38712823
To date, all major modes of monoclonal antibody therapy targeting SARS-CoV-2 have lost significant efficacy against the latest circulating variants. As SARS-CoV-2 omicron sublineages account for over 90% of COVID-19...