Igor Ruiz de Los Mozos
Overview
Explore the profile of Igor Ruiz de Los Mozos including associated specialties, affiliations and a list of published articles.
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23
Citations
884
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Recent Articles
1.
Modic M, Kuret K, Steinhauser S, Faraway R, van Genderen E, Ruiz de Los Mozos I, et al.
Nat Struct Mol Biol
. 2024 Jul;
31(9):1439-1447.
PMID: 39054355
Signaling pathways drive cell fate transitions largely by changing gene expression. However, the mechanisms for rapid and selective transcriptome rewiring in response to signaling cues remain elusive. Here we use...
2.
Fernandez-Calvet A, Matilla-Cuenca L, Izco M, Navarro S, Serrano M, Ventura S, et al.
Nat Commun
. 2024 May;
15(1):4150.
PMID: 38755164
Age-related neurodegenerative diseases involving amyloid aggregation remain one of the biggest challenges of modern medicine. Alterations in the gastrointestinal microbiome play an active role in the aetiology of neurological disorders....
3.
Mas A, Goni E, Ruiz de Los Mozos I, Arcas A, Statello L, Gonzalez J, et al.
Nat Commun
. 2023 Jul;
14(1):4447.
PMID: 37488096
Cells must coordinate the activation of thousands of replication origins dispersed throughout their genome. Active transcription is known to favor the formation of mammalian origins, although the role that RNA...
4.
Balendra R, Ruiz de Los Mozos I, Odeh H, Glaria I, Milioto C, Wilson K, et al.
Life Sci Alliance
. 2023 Jul;
6(9).
PMID: 37438085
An intronic GGGGCC repeat expansion in is a common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. The repeats are transcribed in both sense and antisense directions to generate...
5.
Meraviglia-Crivelli D, Villanueva H, Zheleva A, Villalba-Esparza M, Moreno B, Menon A, et al.
Mol Cancer
. 2022 Nov;
21(1):211.
PMID: 36443756
Background: The quality and quantity of tumor neoantigens derived from tumor mutations determines the fate of the immune response in cancer. Frameshift mutations elicit better tumor neoantigens, especially when they...
6.
Hluchy M, Gajduskova P, Ruiz de Los Mozos I, Rajecky M, Kluge M, Berger B, et al.
Nature
. 2022 Sep;
609(7928):829-834.
PMID: 36104565
RNA splicing, the process of intron removal from pre-mRNA, is essential for the regulation of gene expression. It is controlled by the spliceosome, a megadalton RNA-protein complex that assembles de...
7.
Rovira E, Moreno B, Razquin N, Hjerpe R, Gonzalez-Lopez M, Barrio R, et al.
Mol Ther Nucleic Acids
. 2022 Jun;
28:831-846.
PMID: 35664701
Here, we show that direct recruitment of U1A to target transcripts can increase gene expression. This is a new regulatory role, in addition to previous knowledge showing that U1A decreases...
8.
Karmakar S, Ramirez O, Paul K, Gupta A, Kumari V, Botti V, et al.
NAR Cancer
. 2022 May;
4(2):zcac015.
PMID: 35528200
Musashi 2 (MSI2) is an RNA binding protein (RBP) that regulates asymmetric cell division and cell fate decisions in normal and cancer stem cells. MSI2 appears to repress translation by...
9.
Gong C, Krupka J, Gao J, Grigoropoulos N, Giotopoulos G, Asby R, et al.
Mol Cell
. 2021 Aug;
81(19):4059-4075.e11.
PMID: 34437837
DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for this is unknown. Here,...
10.
Skalska L, Begley V, Beltran M, Lukauskas S, Khandelwal G, Faull P, et al.
Mol Cell
. 2021 Jun;
81(14):2944-2959.e10.
PMID: 34166609
A number of regulatory factors are recruited to chromatin by specialized RNAs. Whether RNA has a more general role in regulating the interaction of proteins with chromatin has not been...