Igor G L Libourel
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Explore the profile of Igor G L Libourel including associated specialties, affiliations and a list of published articles.
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19
Citations
427
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Recent Articles
1.
Krumholz E, Libourel I
Biophys J
. 2017 Aug;
113(3):679-689.
PMID: 28793222
In pursuit of establishing a realistic metabolic phenotypic space, the reversibility of reactions is thermodynamically constrained in modern metabolic networks. The reversibility constraints follow from heuristic thermodynamic poise approximations that...
2.
Bowden S, Palani N, Libourel I
J Microbiol Methods
. 2016 Dec;
133:52-54.
PMID: 28024983
Site specific recombinases are invaluable tools in molecular biology, and are emerging as powerful recorders of cellular events in synthetic biology. We have developed a stringently controlled FLP recombinase system...
3.
Goldford J, Libourel I
Anal Chem
. 2016 May;
88(11):6092-9.
PMID: 27145348
In vivo isotopic labeling coupled with high-resolution proteomics is used to investigate primary metabolism in techniques such as stable isotope probing (protein-SIP) and peptide-based metabolic flux analysis (PMFA). Isotopic enrichment...
4.
Sequence-based Network Completion Reveals the Integrality of Missing Reactions in Metabolic Networks
Krumholz E, Libourel I
J Biol Chem
. 2015 Jun;
290(31):19197-207.
PMID: 26041773
Genome-scale metabolic models are central in connecting genotypes to metabolic phenotypes. However, even for well studied organisms, such as Escherichia coli, draft networks do not contain a complete biochemical network....
5.
Yang H, Krumholz E, Brutinel E, Palani N, Sadowsky M, Odlyzko A, et al.
PLoS Comput Biol
. 2014 Sep;
10(9):e1003848.
PMID: 25233219
Transposon mutagenesis, in combination with parallel sequencing, is becoming a powerful tool for en-masse mutant analysis. A probability generating function was used to explain observed miniHimar transposon insertion patterns, and...
6.
Burdge D, Libourel I
PLoS One
. 2014 Mar;
9(3):e92108.
PMID: 24667828
Bioreactors are designed to support highly controlled environments for growth of tissues, cell cultures or microbial cultures. A variety of bioreactors are commercially available, often including sophisticated software to enhance...
7.
Allen D, Evans B, Libourel I
PLoS One
. 2014 Mar;
9(3):e91537.
PMID: 24626471
Phenotype in multicellular organisms is the consequence of dynamic metabolic events that occur in a spatially dependent fashion. This spatial and temporal complexity presents challenges for investigating metabolism; creating a...
8.
Allen D, Goldford J, Gierse J, Mandy D, Diepenbrock C, Libourel I
Anal Chem
. 2014 Jan;
86(3):1894-901.
PMID: 24387081
Isotopic labeling studies of primary metabolism frequently utilize GC/MS to quantify (13)C in protein-hydrolyzed amino acids. During processing some amino acids are degraded, which reduces the size of the measurement...
9.
Mandy D, Goldford J, Yang H, Allen D, Libourel I
Plant J
. 2013 Nov;
77(3):476-86.
PMID: 24279886
¹³C metabolic flux analysis (MFA) has become the experimental method of choice to investigate the cellular metabolism of microbes, cell cultures and plant seeds. Conventional steady-state MFA utilizes isotopic labeling...
10.
Yang H, Mandy D, Libourel I
Methods Mol Biol
. 2013 Nov;
1083:133-47.
PMID: 24218214
Stable isotope labeling experiments (ILE) constitute a powerful methodology for estimating metabolic fluxes. An optimal label design for such an experiment is necessary to maximize the precision with which fluxes...