Ignacio R Rodriguez
Overview
Explore the profile of Ignacio R Rodriguez including associated specialties, affiliations and a list of published articles.
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23
Citations
917
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Recent Articles
11.
Rodriguez I, Larrayoz I
J Lipid Res
. 2010 Jun;
51(10):2847-62.
PMID: 20567027
This review will discuss the formation and potential implications of 7-ketocholesterol (7KCh) in the retina. 7KCh is a proinflammatory oxysterol known to be present in high amounts in oxidized LDL...
12.
Larrayoz I, Huang J, Lee J, Pascual I, Rodriguez I
Invest Ophthalmol Vis Sci
. 2010 Jun;
51(10):4942-55.
PMID: 20554621
Purpose: 7-Ketocholesterol (7KCh) accumulates in oxidized lipoprotein deposits and is known to be involved in macrophage foam cell formation and atherosclerosis. 7-KCh is present in the primate retina and is...
13.
Pascual I, Larrayoz I, Campos M, Rodriguez I
Exp Eye Res
. 2009 Dec;
90(3):420-8.
PMID: 20026324
Methionine sulfoxide reductase B2 (MSRB2) is a mitochondrial enzyme that converts methionine sulfoxide (R) enantiomer back to methionine. This enzyme is suspected of functioning to protect mitochondrial proteins from oxidative...
14.
Rodriguez I, Fliesler S
Photochem Photobiol
. 2009 Jun;
85(5):1116-25.
PMID: 19500292
Albino Sprague-Dawley rats are known to undergo photoreceptor degeneration after exposure to constant light, but the molecular mechanism(s) by which the photoreceptors degenerate is not fully understood. We hypothesized that...
15.
Moreira E, Larrayoz I, Lee J, Rodriguez I
Invest Ophthalmol Vis Sci
. 2008 Oct;
50(2):523-32.
PMID: 18936140
Purpose: 7-Ketocholesterol is a highly toxic oxysterol found in abundance in atherosclerotic plaques and is believed to play a critical role in atherosclerosis. The purpose of this study was to...
16.
Pascual I, Larrayoz I, Rodriguez I
Genomics
. 2008 Oct;
93(1):62-71.
PMID: 18845237
MSRAs (methionine sulfoxide reductases A) are enzymes that reverse the effects of oxidative damage by reducing methionine sulfoxide back to methionine and recovering protein function. In this study we demonstrate...
17.
Moreira E, Kantorow M, Rodriguez I
Exp Eye Res
. 2007 Dec;
86(2):452-5.
PMID: 18078932
Oxidative stress and loss of mitochondrial function have been implicated in age-related ocular diseases and thus studying enzymes involved in these processes may be of particular importance in these diseases....
18.
Tserentsoodol N, Gordiyenko N, Pascual I, Lee J, Fliesler S, Rodriguez I
Mol Vis
. 2006 Nov;
12:1319-33.
PMID: 17110915
Purpose: In our companion paper we demonstrated that circulating lipoproteins enter the retina via the retinal pigment epithelium (RPE) and possibly Müller cells. In order to understand how these lipids...
19.
Tserentsoodol N, Sztein J, Campos M, Gordiyenko N, Fariss R, Lee J, et al.
Mol Vis
. 2006 Nov;
12:1306-18.
PMID: 17110914
Purpose: In this study we examined the uptake of circulating lipoproteins into the retina, using a naturally fluorescent cholesterol analog for imaging and deuterated cholesterol for quantification by mass spectroscopy....
20.
Lee J, Fuda H, Javitt N, Strott C, Rodriguez I
Exp Eye Res
. 2006 Mar;
83(2):465-9.
PMID: 16549062
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial P-450 enzyme with broad substrate specificity for C27 sterols including 7-ketocholesterol (7kCh). CYP27A1 is widely expressed in human tissues but has not been previously...