Ignacio Benedicto
Overview
Explore the profile of Ignacio Benedicto including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
995
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Recent Articles
1.
Benedicto I, Hamczyk M, Nevado R, Barettino A, Carmona R, Espinos-Estevez C, et al.
Aging Cell
. 2024 Oct;
24(2):e14389.
PMID: 39479939
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by a mutation in the LMNA gene that provokes the synthesis of progerin, a mutant version of the nuclear protein...
2.
Barettino A, Gonzalez-Gomez C, Gonzalo P, Andres-Manzano M, Guerrero C, Espinosa F, et al.
J Clin Invest
. 2024 Oct;
134(22).
PMID: 39352768
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare disease caused by the expression of progerin, an aberrant protein produced by a point mutation in the LMNA gene. HGPS patients show...
3.
Benedicto I, Carmona R, Barettino A, Espinos-Estevez C, Gonzalo P, Nevado R, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(18):e2400752121.
PMID: 38648484
Hutchinson-Gilford progeria syndrome (HGPS) is a rare disease caused by the expression of progerin, a mutant protein that accelerates aging and precipitates death. Given that atherosclerosis complications are the main...
4.
Macias A, Nevado R, Gonzalez-Gomez C, Gonzalo P, Andres-Manzano M, Dorado B, et al.
Geroscience
. 2023 May;
46(1):867-884.
PMID: 37233881
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disease caused by expression of progerin, a lamin A variant that is also expressed at low levels in non-HGPS individuals. Although...
5.
Lehmann G, Ginsberg M, Nolan D, Rodriguez C, Martinez-Gonzalez J, Zeng S, et al.
Cells
. 2022 Oct;
11(19).
PMID: 36230937
Alpha-2-macroglobulin (A2M) is a protease inhibitor that regulates extracellular matrix (ECM) stability and turnover. Here, we show that A2M is expressed by endothelial cells (ECs) from human eye choroid. We...
6.
Benedicto I, Chen X, Bergo M, Andres V
Expert Opin Ther Targets
. 2022 May;
26(5):393-399.
PMID: 35575136
No abstract available.
7.
Barettino A, Benedicto I, Andres V
Methods Mol Biol
. 2022 Mar;
2419:597-610.
PMID: 35237991
Confocal imaging of the mouse aorta is a powerful, indispensable technique for the study of cardiovascular pathology ex vivo. Whole mount en face preparations allow visualization of wide areas of...
8.
Pan C, Banerjee K, Lehmann G, Almeida D, Hajjar K, Benedicto I, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(47).
PMID: 34782457
Lipofuscin granules enclose mixtures of cross-linked proteins and lipids in proportions that depend on the tissue analyzed. Retinal lipofuscin is unique in that it contains mostly lipids with very little...
9.
Sanchez-Lopez A, Espinos-Estevez C, Gonzalez-Gomez C, Gonzalo P, Andres-Manzano M, Fanjul V, et al.
Circulation
. 2021 Oct;
144(22):1777-1794.
PMID: 34694158
Background: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder characterized by premature aging and death mainly because of myocardial infarction, stroke, or heart failure. The disease is provoked by progerin,...
10.
Hanke-Gogokhia C, Lehmann G, Benedicto I, De la Fuente-Ortega E, Arshavsky V, Schreiner R, et al.
FASEB J
. 2021 Jun;
35(7):e21689.
PMID: 34085737
Knockout of the chloride channel protein 2 (CLC-2; CLCN2) results in fast progressing blindness in mice. Retinal Pigment Epithelium (RPE) and photoreceptors undergo, in parallel, rapid, and profound morphological changes...