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Ida J van der Klei

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Articles 141
Citations 8450
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Recent Articles
1.
Kosir T, Das H, Pedersen M, Richard A, Anteghini M, Martins Dos Santos V, et al.
Microb Cell . 2025 Feb; 12:9-33. PMID: 40012703
Peroxisomes are organelles that are crucial for cellular metabolism, but they also play important roles in non-metabolic processes such as signalling, stress response or antiviral defense. To uncover the consequences...
2.
de Lange E, Mol F, van der Klei I, Vlijm R
iScience . 2024 Aug; 27(8):110481. PMID: 39156652
Peroxisomes are dynamic organelles with important metabolic functions. Yeast Pex3 is a multifunctional membrane protein aiding in peroxisomal biogenesis, inheritance, and degradation (pexophagy), by interacting with process-specific factors. Using multicolor...
3.
Jansen R, de Boer R, de Lange E, Koster J, Vlijm R, Waterham H, et al.
Biochim Biophys Acta Mol Cell Res . 2024 May; 1871(6):119754. PMID: 38762172
Peroxisome biogenesis disorders are caused by pathogenic variants in genes involved in biogenesis and maintenance of peroxisomes. However, mitochondria are also often affected in these diseases. Peroxisomal membrane proteins, including...
4.
Pedersen M, Wolters J, de Boer R, Krikken A, van der Klei I
Biochim Biophys Acta Mol Cell Res . 2024 May; 1871(5):119742. PMID: 38702017
Peroxisomes are ubiquitous cell organelles involved in various metabolic pathways. In order to properly function, several cofactors, substrates and products of peroxisomal enzymes need to pass the organellar membrane. So...
5.
Wu F, de Boer R, van der Klei I
J Cell Sci . 2023 Jun; 136(11). PMID: 37288671
Membrane contact sites are defined as regions of close proximity between two membranes; this association is mediated by protein-protein and/or protein-lipid interactions. Contact sites are often involved in lipid transport,...
6.
Jansen R, van den Noort M, Krikken A, Bibi C, Bohm A, Schuldiner M, et al.
Biochim Biophys Acta Mol Cell Res . 2023 Apr; 1870(5):119471. PMID: 37028652
The mechanism behind peroxisomal membrane protein targeting is still poorly understood, with only two yeast proteins believed to be involved and no consensus targeting sequence. Pex19 is thought to bind...
7.
de Boer R, van der Klei I
Methods Mol Biol . 2023 Mar; 2643:93-104. PMID: 36952180
Correlative light and electron microscopy (CLEM) combines the advantages of protein localization by fluorescence microscopy with the high resolution of electron microscopy. Here, we describe a protocol that we developed...
8.
Wu F, van der Klei I
Front Cell Dev Biol . 2022 Aug; 10:957871. PMID: 36016650
In the yeast , the ER protein Pex32 is required for associating peroxisomes to the ER. Here, we report on a structure-function analysis of Pex32. Localization studies of various Pex32...
9.
Yuan W, Aksit A, de Boer R, Krikken A, van der Klei I
Front Cell Dev Biol . 2022 Mar; 10:842285. PMID: 35252206
In the yeast the peroxisomal membrane protein Pex11 and three endoplasmic reticulum localized proteins of the Pex23 family (Pex23, Pex24 and Pex32) are involved in the formation of peroxisome-ER contact...
10.
Jansen R, Santana-Molina C, van den Noort M, Devos D, van der Klei I
Front Cell Dev Biol . 2021 Jun; 9:654163. PMID: 34095119
PEX genes encode proteins involved in peroxisome biogenesis and proliferation. Using a comparative genomics approach, we clarify the evolutionary relationships between the 37 known PEX proteins in a representative set...