Martin van der Laan
Overview
Explore the profile of Martin van der Laan including associated specialties, affiliations and a list of published articles.
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99
Citations
3535
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Recent Articles
1.
Zerbes R, Colina-Tenorio L, Bohnert M, von der Malsburg K, Peikert C, Mehnert C, et al.
EMBO Rep
. 2024 Dec;
26(2):353-384.
PMID: 39623166
The boundary and cristae domains of the mitochondrial inner membrane are connected by crista junctions. Most cristae membrane proteins are nuclear-encoded and inserted by the mitochondrial protein import machinery into...
2.
Horten P, Song K, Garlich J, Hardt R, Colina-Tenorio L, Horvath S, et al.
Cell Rep
. 2024 Feb;
43(3):113772.
PMID: 38393949
The mitochondrial inner membrane plays central roles in bioenergetics and metabolism and contains several established membrane protein complexes. Here, we report the identification of a mega-complex of the inner membrane,...
3.
von der Malsburg A, Sapp G, Zuccaro K, von Appen A, Moss 3rd F, Kalia R, et al.
Nature
. 2023 Aug;
620(7976):1101-1108.
PMID: 37612504
Distinct morphologies of the mitochondrial network support divergent metabolic and regulatory processes that determine cell function and fate. The mechanochemical GTPase optic atrophy 1 (OPA1) influences the architecture of cristae...
4.
Fielden L, Busch J, Merkt S, Ganesan I, Steiert C, Hasselblatt H, et al.
Nature
. 2023 Aug;
621(7979):627-634.
PMID: 37527780
The presequence translocase of the mitochondrial inner membrane (TIM23) represents the major route for the import of nuclear-encoded proteins into mitochondria. About 60% of more than 1,000 different mitochondrial proteins...
5.
Bock-Bierbaum T, Funck K, Wollweber F, Lisicki E, von der Malsburg K, von der Malsburg A, et al.
Sci Adv
. 2022 Aug;
8(35):eabo4946.
PMID: 36044574
Mitochondrial cristae membranes are the oxidative phosphorylation sites in cells. Crista junctions (CJs) form the highly curved neck regions of cristae and are thought to function as selective entry gates...
6.
Priesnitz C, Bottinger L, Zufall N, Gebert M, Guiard B, van der Laan M, et al.
Cell Rep
. 2022 Apr;
39(1):110619.
PMID: 35385740
The presequence translocase (TIM23 complex) imports precursor proteins into the mitochondrial inner membrane and matrix. The presequence translocase-associated motor (PAM) provides a driving force for transport into the matrix. The...
7.
Rampelt H, Wollweber F, Licheva M, de Boer R, Perschil I, Steidle L, et al.
Cell Rep
. 2022 Jan;
38(4):110290.
PMID: 35081352
Invaginations of the mitochondrial inner membrane, termed cristae, are hubs for oxidative phosphorylation. The mitochondrial contact site and cristae organizing system (MICOS) and the dimeric FF-ATP synthase play important roles...
8.
Bertero E, Nickel A, Kohlhaas M, Hohl M, Sequeira V, Brune C, et al.
Circulation
. 2021 Oct;
144(21):1694-1713.
PMID: 34648376
Background: Barth syndrome (BTHS) is caused by mutations of the gene encoding tafazzin, which catalyzes maturation of mitochondrial cardiolipin and often manifests with systolic dysfunction during early infancy. Beyond the...
9.
Kurokin I, Lauer A, Janitschke D, Winkler J, Theiss E, Griebsch L, et al.
Biomedicines
. 2021 Aug;
9(8).
PMID: 34440266
Alzheimer's disease (AD) is neuropathologically characterized by the accumulation of Amyloid-β (Aβ) in senile plaques derived from amyloidogenic processing of a precursor protein (APP). Recently, changes in mitochondrial function have...
10.
Lauterwasser J, Fimm-Todt F, Oelgeklaus A, Schreiner A, Funk K, Falquez-Medina H, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(33).
PMID: 34385311
Death receptor-mediated apoptosis requires the mitochondrial apoptosis pathway in many mammalian cells. In response to death receptor signaling, the truncated BH3-only protein BID can activate the proapoptotic BCL-2 proteins BAX...