Ibrahim A Al-Suwaidan
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Explore the profile of Ibrahim A Al-Suwaidan including associated specialties, affiliations and a list of published articles.
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15
Citations
175
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Recent Articles
1.
Abdel-Aziz A, El-Azab A, Brogi S, Ayyad R, Al-Suwaidan I, Hefnawy M
Int J Mol Sci
. 2025 Jan;
25(24.
PMID: 39769383
Five phenolic Schiff bases (-) incorporating a fragment of methanesulfonamide were synthesized and evaluated for their efficacy as antitumor agents. Compounds and demonstrated the most potent antitumor action, with a...
2.
El-Azab A, Abdel-Aziz A, Bakheit A, Alkahtani H, Obaidullah A, Hefnawy M, et al.
RSC Adv
. 2025 Jan;
15(1):541-558.
PMID: 39763619
We tested newly synthesized compounds 1-13 on 59 cancer cell lines and found that acylhydrazones 5, 6, 7, 9, and 12 showed the best cytotoxic activity. They stopped the mean...
3.
Abdel-Aziz A, El-Azab A, Brogi S, Ayyad R, Alkahtani H, Abuelizz H, et al.
RSC Adv
. 2024 Jul;
14(31):22132-22146.
PMID: 39005246
Antitumor activity using 59 cancer cell lines and enzyme inhibitory activity of a newly synthesized pyrazoline-linked 4-methylsulfonylphenyl scaffold (compounds 18a-q) were measured and compared with those of standard drugs. Pyrazolines...
4.
Alnasser A, Hefnawy M, Al-Hossaini A, Bin Jardan Y, El-Azab A, Abdel-Aziz A, et al.
Saudi Pharm J
. 2023 Aug;
31(9):101693.
PMID: 37559870
This study developed a novel, sensitive and selective LC-MS/MS method for the concurrent determination of DCB and VTX in rat plasma using encorafenib as internal standard (IS). To identify DCB,...
5.
Abdel-Aziz A, El-Azab A, Alsaif N, Obaidullah A, Al-Obaid A, Al-Suwaidan I
J Enzyme Inhib Med Chem
. 2021 Jul;
36(1):1521-1539.
PMID: 34266349
Hydrazone is a bioactive pharmacophore that can be used to design antitumor agents. We synthesised a series of hydrazones (compounds ) incorporating a 4-methylsulfonylbenzene scaffold and analysed their potential antitumor...
6.
Abdel-Aziz A, El-Azab A, Alsaif N, Alanazi M, El-Gendy M, Obaidullah A, et al.
J Enzyme Inhib Med Chem
. 2020 Feb;
35(1):610-621.
PMID: 32013633
Cyclic imides containing 3-benzenesulfonamide, oxime, and β-phenylalanine derivatives were synthesised and evaluated to elucidate their anti-inflammatory and ulcerogenic activity and cytotoxic effects. Most active anti-inflammatory agents were subjected to COX-1/2...
7.
El-Azab A, Abdel-Aziz A, Bua S, Nocentini A, Alanazi M, Alsaif N, et al.
Bioorg Chem
. 2019 Sep;
92:103225.
PMID: 31493707
Herein, we report the synthesis, characterization, and carbonic anhydrase (CA) inhibition of the newly synthesized Schiff's bases 4-18 with benzenesulfonamide, methanesulfonamide, and methylsulfonylbenzene scaffolds. The compound inhibition profiles against human...
8.
Abdel-Aziz A, El-Azab A, Alanazi A, Asiri Y, Al-Suwaidan I, Maarouf A, et al.
J Enzyme Inhib Med Chem
. 2015 Jul;
31(5):796-809.
PMID: 26226179
The potential antitumor activities of a series of 7-(4-substituted piperazin-1-yl)fluoroquinolone derivatives (1-14a,b) using ciprofloxacin and norfloxacin as scaffolds are described. These compounds exhibit potent and broad spectrum antitumor activities using...
9.
Al-Suwaidan I, Abdel-Aziz A, Shawer T, Ayyad R, Alanazi A, El-Morsy A, et al.
J Enzyme Inhib Med Chem
. 2015 Mar;
31(1):78-89.
PMID: 25815668
A novel series of 3-benzyl-substituted-4(3H)-quinazolinones were designed, synthesized and evaluated for their in vitro antitumor activity. The results of this study demonstrated that 2-(3-benzyl-6-methyl-4-oxo-3,4-dihydroquinazolin-2-ylthio)-N-(3,4,5-trimethoxyphenyl)acetamide, 2-(3-benzyl-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-ylthio)-N-(3,4,5-trimethoxyphenyl)acetamide and 3-(3-benzyl-6-methyl-4-oxo-3,4-dihydroquinazolin-2-ylthio)-N-(3,4,5-trimethoxyphenyl)-propanamide have shown amazing...
10.
Alanazi A, El-Azab A, Al-Suwaidan I, ElTahir K, Asiri Y, Abdel-Aziz N, et al.
Eur J Med Chem
. 2015 Jan;
92:115-23.
PMID: 25549551
A group of 30 cyclic imides (1-10a-c) was designed for evaluation as a selective COX-2 inhibitor and investigated in vivo for anti-inflammatory and analgesic activities. Compounds 6a, 6b, 7a and...