Ian T Mathews
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Explore the profile of Ian T Mathews including associated specialties, affiliations and a list of published articles.
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15
Citations
470
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Recent Articles
1.
Mathews I, Saminathan P, Henglin M, Liu M, Nadig N, Fang C, et al.
medRxiv
. 2024 Aug;
PMID: 39148854
Immune related adverse events (irAEs) after immune checkpoint blockade (ICB) therapy occur in a significant proportion of cancer patients. To date, the circulating mediators of ICB-irAEs remain poorly understood. Using...
2.
Reina-Campos M, Heeg M, Kennewick K, Mathews I, Galletti G, Luna V, et al.
Nature
. 2023 Aug;
621(7977):179-187.
PMID: 37648857
Tissue resident memory CD8 T (T) cells offer rapid and long-term protection at sites of reinfection. Tumour-infiltrating lymphocytes with characteristics of T cells maintain enhanced effector functions, predict responses to...
3.
Lui A, Kallis K, Zhong A, Hussain T, Conlin C, Digma L, et al.
Int J Radiat Oncol Biol Phys
. 2023 Jul;
117(5):1145-1152.
PMID: 37453559
Purpose: In a phase III randomized trial, adding a radiation boost to tumor(s) visible on MRI improved prostate cancer (PCa) disease-free and metastasis-free survival without additional toxicity. Radiation oncologists' ability...
4.
Ward C, Nallamshetty S, Watrous J, Acres E, Long T, Mathews I, et al.
J Mass Spectrom
. 2021 Jul;
56(8):e4772.
PMID: 34240506
Advances in high-resolution, nontargeted mass spectrometry allow for the simultaneous measure of thousands of metabolites in a single biosample. Application of these analytical approaches to population-scale human studies has been...
5.
Chu X, Jaeger M, Beumer J, Bakker O, Aguirre-Gamboa R, Oosting M, et al.
Genome Biol
. 2021 Jul;
22(1):198.
PMID: 34229738
Background: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. Result: We...
6.
Kushnareva Y, Mathews I, Andreyev A, Altay G, Arlehamn C, Pandurangan V, et al.
J Immunol
. 2021 Feb;
206(6):1181-1193.
PMID: 33547171
CCR6CXCR3CCR4CD4 memory T cells, termed Th1*, are important for long-term immunity to and the pathogenesis of autoimmune diseases. Th1* cells express a unique set of lineage-specific transcription factors characteristic of...
7.
Dhanwani R, Takahashi M, Mathews I, Lenzi C, Romanov A, Watrous J, et al.
Sci Adv
. 2020 Aug;
6(30):eaba3688.
PMID: 32743071
Mechanisms linking immune sensing of DNA danger signals in the extracellular environment to innate pathways in the cytosol are poorly understood. Here, we identify a previously unidentified immune-metabolic axis by...
8.
Lowey B, Whiteley A, Keszei A, Morehouse B, Mathews I, Antine S, et al.
Cell
. 2020 Jun;
182(1):38-49.e17.
PMID: 32544385
cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes are immune sensors that synthesize nucleotide second messengers and initiate antiviral responses in bacterial and animal cells. Here, we discover Enterobacter cloacae CD-NTase-associated protein 4 (Cap4)...
9.
Ye Q, Lau R, Mathews I, Birkholz E, Watrous J, Azimi C, et al.
Mol Cell
. 2020 Jan;
77(4):709-722.e7.
PMID: 31932165
Bacteria are continually challenged by foreign invaders, including bacteriophages, and have evolved a variety of defenses against these invaders. Here, we describe the structural and biochemical mechanisms of a bacteriophage...
10.
Lau R, Ye Q, Birkholz E, Berg K, Patel L, Mathews I, et al.
Mol Cell
. 2020 Jan;
77(4):723-733.e6.
PMID: 31932164
Bacteria possess an array of defenses against foreign invaders, including a broadly distributed bacteriophage defense system termed CBASS (cyclic oligonucleotide-based anti-phage signaling system). In CBASS systems, a cGAS/DncV-like nucleotidyltransferase synthesizes...