David Sims
Overview
Explore the profile of David Sims including associated specialties, affiliations and a list of published articles.
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92
Citations
4000
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Recent Articles
1.
Bird F, Bird F, Wilson M, Aziz S, Shebl M, Pickard A, et al.
Int J Surg
. 2025 Feb;
111(3):2516-2524.
PMID: 39903519
Background: The relationship between early cardiovascular dysfunction (CVD) in isolated traumatic brain injury (iTBI) and outcome has not been fully described. We aimed to (1) determine the prevalence and phenotype...
2.
Schoenfeld J, Azad N, Gross J, Chen L, Overman M, Kao K, et al.
Clin Cancer Res
. 2024 Dec;
31(4):667-677.
PMID: 39670863
Purpose: Mismatch repair-deficient (dMMR) tumors have demonstrated favorable responses to immune checkpoint inhibition targeting PD-1. However, more in-depth identification of predictors of response could further refine patient selection for immunotherapy...
3.
Curion F, Rich-Griffin C, Agarwal D, Ouologuem S, Rue-Albrecht K, May L, et al.
Genome Biol
. 2024 Jul;
25(1):181.
PMID: 38978088
Single-cell multiomic analysis of the epigenome, transcriptome, and proteome allows for comprehensive characterization of the molecular circuitry that underpins cell identity and state. However, the holistic interpretation of such datasets...
4.
Sharma A, Ramlee M, Kosmin J, Higgs M, Wolstenholme A, Ronson G, et al.
Nat Commun
. 2023 Nov;
14(1):7784.
PMID: 38012134
No abstract available.
5.
Tolonen J, Parolin Schnekenberg R, McGowan S, Sims D, McEntagart M, Elmslie F, et al.
Mov Disord
. 2023 Nov;
39(1):141-151.
PMID: 37964426
Background: The ITPR1 gene encodes the inositol 1,4,5-trisphosphate (IP ) receptor type 1 (IP R1), a critical player in cerebellar intracellular calcium signaling. Pathogenic missense variants in ITPR1 cause congenital...
6.
Weeratunga P, Denney L, Bull J, Repapi E, Sergeant M, Etherington R, et al.
Nat Commun
. 2023 Nov;
14(1):7216.
PMID: 37940670
Single cell spatial interrogation of the immune-structural interactions in COVID -19 lungs is challenging, mainly because of the marked cellular infiltrate and architecturally distorted microstructure. To address this, we develop...
7.
Sharma A, Ramlee M, Kosmin J, Higgs M, Wolstenholme A, Ronson G, et al.
Nat Commun
. 2023 Aug;
14(1):5003.
PMID: 37591890
While the toxicity of PARP inhibitors to cells with defects in homologous recombination (HR) is well established, other synthetic lethal interactions with PARP1/PARP2 disruption are poorly defined. To inform on...
8.
Downes D, Smith A, Karpinska M, Velychko T, Rue-Albrecht K, Sims D, et al.
Nat Protoc
. 2023 Jun;
18(10):3155.
PMID: 37369851
No abstract available.
9.
Jamali H, Nicholas D, Sims D, Watkinson A, Herman E, Boukacem-Zeghmouri C, et al.
PLoS One
. 2023 Feb;
18(2):e0281058.
PMID: 36791119
Introduction: As part of the Harbnger-2 project, this study aimed to discover the impact of the COVID-19 pandemic on junior researchers' work-life, career prospects, research and publishing practices and networking....
10.
Park A, Croset V, Otto N, Agarwal D, Treiber C, Meschi E, et al.
Curr Biol
. 2022 Aug;
32(18):3952-3970.e8.
PMID: 35963239
Thirst emerges from a range of cellular changes that ultimately motivate an animal to consume water. Although thirst-responsive neuronal signals have been reported, the full complement of brain responses is...