Ian C Mackenzie
Overview
Explore the profile of Ian C Mackenzie including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
25
Citations
853
Followers
0
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Youssef G, Gammon L, Ambler L, Lunetto S, Scemama A, Cottom H, et al.
Elife
. 2023 Nov;
12.
PMID: 37975646
Cancer stem cells (CSCs) undergo epithelial-mesenchymal transition (EMT) to drive metastatic dissemination in experimental cancer models. However, tumour cells undergoing EMT have not been observed disseminating into the tissue surrounding...
2.
Das R, Harper L, Kitajima K, Osman T, Cimpan M, Johannssen A, et al.
Int J Mol Sci
. 2023 May;
24(9).
PMID: 37175400
We aimed to investigate whether molecular clues from the extracellular matrix (ECM) can induce oral epithelial differentiation of pluripotent stem cells. Mouse embryonic stem cells (ESC) of the feeder-independent cell...
3.
Pang X, OMalley C, Borges J, Rahman M, Collis D, Mano J, et al.
Adv Biosyst
. 2020 Jul;
3(10):e1900017.
PMID: 32648721
The supramolecular presentation of extracellular matrix components on surfaces provides a platform for the investigation and control of cell behavior. Hyaluronan (HA) is one of the main components of the...
4.
Rodrigues M, Gammon L, Rahman M, Biddle A, Nunes F, Mackenzie I
Oncotarget
. 2018 Mar;
9(17):13488-13500.
PMID: 29568372
The therapeutic responses of many solid tumours to chemo- and radio-therapies are far from fully effective but therapies targeting malignancy-related cellular changes show promise for further control. In head and...
5.
Biddle A, Gammon L, Liang X, Costea D, Mackenzie I
EBioMedicine
. 2016 Mar;
4:138-45.
PMID: 26981578
Cancer stem cells (CSCs) drive tumour spread and therapeutic resistance, and can undergo epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) to switch between epithelial and post-EMT sub-populations. Examining oral squamous...
6.
Gemenetzidis E, Gammon L, Biddle A, Emich H, Mackenzie I
Oncotarget
. 2015 Nov;
6(41):43964-77.
PMID: 26540568
There is a significant amount of evidence to suggest that human tumors are driven and maintained by a sub-population of cells, known as cancer stem cells (CSC). In the case...
7.
Gammon L, Mackenzie I
J Oral Pathol Med
. 2015 May;
45(2):77-82.
PMID: 25952002
Evidence from a wide range of studies indicates that hypoxia and the resulting cellular changes that are induced by HIF-1α lead to transcriptional up-regulation of a diversity of genes that...
8.
Jensen D, Reibel J, Mackenzie I, Dabelsteen E
J Oral Pathol Med
. 2015 Apr;
44(9):674-9.
PMID: 25880532
Background: The invasion of cancer cells into the surrounding normal tissue is one of the defining features of cancer. While the phenomena of tumour budding, epithelial-mesenchymal transition and the presence...
9.
Vig N, Mackenzie I, Biddle A
J Oral Pathol Med
. 2015 Jan;
44(9):649-55.
PMID: 25594908
It is increasingly recognised that phenotypic plasticity, apparently driven by epigenetic mechanisms, plays a key role in tumour behaviour and markedly influences the important processes of therapeutic survival and metastasis....
10.
Shigeishi H, Biddle A, Gammon L, Rodini C, Yamasaki M, Seino S, et al.
J Oral Pathol Med
. 2014 Aug;
44(3):201-7.
PMID: 25169655
Background: Cancer stem cells (CSCs) are involved in both tumourigenesis and in tumour recurrence after therapy. In head and neck squamous cell carcinoma (HNSCC), there are two biologically different CSC...