Ian C Mackenzie
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Explore the profile of Ian C Mackenzie including associated specialties, affiliations and a list of published articles.
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25
Citations
853
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Recent Articles
11.
Bose A, Teh M, Mackenzie I, Waseem A
Int J Mol Sci
. 2013 Sep;
14(10):19385-98.
PMID: 24071939
Keratin 15 (K15) is type I keratin protein co-expressed with the K5/K14 pair present in the basal keratinocytes of all stratified epithelia. Although it is a minor component of the...
12.
Shigeishi H, Biddle A, Gammon L, Emich H, Rodini C, Gemenetzidis E, et al.
Stem Cells
. 2013 May;
31(10):2073-83.
PMID: 23649588
Cells sorted from head and neck cancers on the basis of their high expression of CD44 have high potency for tumor initiation. These cells are also involved in epithelial to...
13.
Gammon L, Biddle A, Heywood H, Johannessen A, Mackenzie I
PLoS One
. 2013 May;
8(4):e62493.
PMID: 23638097
The glycolytic response of hypoxic cells is primarily mediated by the hypoxia inducible factor alpha (HIF-1α) but even in the presence of abundant oxygen tumours typically show high rates of...
14.
Biddle A, Gammon L, Fazil B, Mackenzie I
PLoS One
. 2013 Feb;
8(2):e57314.
PMID: 23437366
CD44 is commonly used as a cell surface marker of cancer stem-like cells in epithelial tumours, and we have previously demonstrated the existence of two different CD44(high) cancer stem-like cell...
15.
Wray H, Mackenzie I, Storey A, Navsaria H
PLoS One
. 2012 Oct;
7(10):e46968.
PMID: 23071680
Epidermal human keratinocytes are exposed to a wide range of environmental genotoxic insults, including the UV component of solar radiation. Epidermal homeostasis in response to cellular or tissue damage is...
16.
Biddle A, Mackenzie I
Cancer Metastasis Rev
. 2012 Feb;
PMID: 22302111
The majority of deaths from carcinoma are caused by secondary growths that result from tumour invasion and metastasis. The importance of epithelial-to-mesenchymal transition (EMT) as a driver of invasion and...
17.
Biddle A, Liang X, Gammon L, Fazil B, Harper L, Emich H, et al.
Cancer Res
. 2011 Jun;
71(15):5317-26.
PMID: 21685475
Epithelial-to-mesenchymal transition (EMT) is an important driver of tumor invasion and metastasis, which causes many cancer deaths. Cancer stem cells (CSC) that maintain and initiate tumors have also been implicated...
18.
Gammon L, Biddle A, Fazil B, Harper L, Mackenzie I
J Oral Pathol Med
. 2010 Dec;
40(2):143-52.
PMID: 21138479
Increasing evidence indicates that cancer growth is driven by a sub-population of self-renewing cancer stem cells (CSCs) and that clinical problems of tumor recurrence after therapy may be related to...
19.
Harper L, Costea D, Gammon L, Fazil B, Biddle A, Mackenzie I
BMC Cancer
. 2010 Apr;
10:166.
PMID: 20426848
Background: Subsets of cells with stem-like properties have been previously isolated from human epithelial cancers and their resistance to apoptosis-inducing stimuli has been related to carcinoma recurrence and treatment failure....
20.
Costea D, Gammon L, Kitajima K, Harper L, Mackenzie I
J Anat
. 2008 Jul;
213(1):45-51.
PMID: 18638069
The renewal of normal epithelia depends on a small sub-population of cells, termed somatic stem cells, whose primary characteristic is an ability for indefinite self-renewal. Evidence is accumulating that the...