Ian B Robertson
Overview
Explore the profile of Ian B Robertson including associated specialties, affiliations and a list of published articles.
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14
Citations
667
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Recent Articles
1.
Robertson I, Mulvaney R, Dieckmann N, Vantellini A, Canestraro M, Amicarella F, et al.
Clin Exp Immunol
. 2023 Nov;
215(2):105-119.
PMID: 37930865
T-cell-engaging bispecifics have great clinical potential for the treatment of cancer and infectious diseases. The binding affinity and kinetics of a bispecific molecule for both target and T-cell CD3 have...
2.
Robertson I, Dias H, Osuch I, Lowe E, Jensen S, Redfield C, et al.
Structure
. 2017 Jul;
25(8):1208-1221.e5.
PMID: 28669633
Fibrillin-1 (FBN1) mutations associated with Marfan syndrome lead to an increase in transforming growth factor β (TGF-β) activation in connective tissues resulting in pathogenic changes including aortic dilatation and dissection....
3.
Robertson I, Rifkin D
Cold Spring Harb Perspect Biol
. 2016 Jun;
8(6).
PMID: 27252363
The bioavailability of members of the transforming growth factor β (TGF-β) family is controlled by a number of mechanisms. Bona fide TGF-β is sequestered into the matrix in a latent...
4.
Robertson I, Horiguchi M, Zilberberg L, Dabovic B, Hadjiolova K, Rifkin D
Matrix Biol
. 2015 May;
47:44-53.
PMID: 25960419
The LTBPs (or latent transforming growth factor β binding proteins) are important components of the extracellular matrix (ECM) that interact with fibrillin microfibrils and have a number of different roles...
5.
Dabovic B, Robertson I, Zilberberg L, Vassallo M, Davis E, Rifkin D
J Cell Physiol
. 2014 Jun;
230(1):226-36.
PMID: 24962333
Mice deficient in Latent TGFβ Binding Protein 4 (Ltbp4) display a defect in lung septation and elastogenesis. The lung septation defect is normalized by genetically decreasing TGFβ2 levels. However, the...
6.
Robertson I, Handford P, Redfield C
PLoS One
. 2014 Feb;
9(1):e87125.
PMID: 24489852
Proteins from the LTBP/fibrillin family perform key structural and functional roles in connective tissues. LTBP1 forms the large latent complex with TGFβ and its propeptide LAP, and sequesters the latent...
7.
Yadin D, Robertson I, McNaught-Davis J, Evans P, Stoddart D, Handford P, et al.
Structure
. 2013 Sep;
21(10):1743-56.
PMID: 24035709
The human extracellular matrix glycoprotein fibrillin-1 is the primary component of the 10- to 12-nm-diameter microfibrils, which perform key structural and regulatory roles in connective tissues. Relatively little is known...
8.
Robertson I, Rifkin D
Cytokine Growth Factor Rev
. 2013 Jul;
24(4):355-72.
PMID: 23849989
TGFβ is secreted in a latent state and must be "activated" by molecules that facilitate its release from a latent complex and allow binding to high affinity cell surface receptors....
9.
Robertson I, Osuch I, Yadin D, Handford P, Jensen S, Redfield C
Biomol NMR Assign
. 2013 May;
8(1):189-94.
PMID: 23649688
Fibrillins are large extracellular glycoproteins that form the principal component of microfibrils. These perform a vital structural function in the extracellular matrix of many tissues. Fibrillins have also been implicated...
10.
Robertson I, Handford P, Redfield C
Biomol NMR Assign
. 2013 Mar;
8(1):159-63.
PMID: 23494870
Latent TGFβ binding protein 1 (LTBP1) is a large extracellular protein that has been shown to bind covalently to the propeptide of TGFβ cytokines and form a large latent complex,...