Iain R Greig
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Explore the profile of Iain R Greig including associated specialties, affiliations and a list of published articles.
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25
Citations
484
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Recent Articles
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Zhai D, Yan S, Samsom J, Wang L, Su P, Jiang A, et al.
Sci Adv
. 2023 Dec;
9(49):eadj6187.
PMID: 38064562
While most research and treatments for multiple sclerosis (MS) focus on autoimmune reactions causing demyelination, it is possible that neurodegeneration precedes the autoimmune response. Hence, glutamate receptor antagonists preventing excitotoxicity...
3.
Green H, Finlay D, Ross R, Greig I, Duffull S, Glass M
ACS Pharmacol Transl Sci
. 2022 Dec;
5(12):1279-1291.
PMID: 36524007
Orthosteric activation of CB is known to cause a plethora of adverse side effects . Allosteric modulation is an exciting therapeutic approach and is hoped to offer improved therapeutic potential...
4.
Gorberg V, Borisov V, Greig I, Pertwee R, McCaffery P, Anavi-Goffer S
Mol Neurobiol
. 2022 Jun;
59(8):5070-5083.
PMID: 35666403
Δ-Tetrahydrocannabinol (Δ-THC) inhibits tics in individuals with Tourette syndrome (TS). Δ-THC has similar affinities for CB/CB cannabinoid receptors. However, the effect of HU-308, a selective CB receptor agonist, on repetitive...
5.
Nashed M, Waye S, Hasan S, Nguyen D, Wiseman M, Zhang J, et al.
Psychopharmacology (Berl)
. 2022 Jan;
239(1):253-266.
PMID: 34982171
Rationale: The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is implicated in the pathophysiology of depressive disorders. Objective: We ascertained whether the SK...
6.
Mielnik C, Sugamori K, Finlay D, Thorpe H, Schapira M, Sivananthan N, et al.
Neuropsychopharmacology
. 2020 Oct;
46(2):413-422.
PMID: 33036015
The endocannabinoid system (eCBs) encompasses the endocannabinoids, their synthetic and degradative enzymes, and cannabinoid (CB) receptors. The eCBs mediates inhibition of neurotransmitter release and acts as a major homeostatic system....
7.
Tseng C, Baillie G, Donvito G, Mustafa M, Juola S, Zanato C, et al.
J Med Chem
. 2019 May;
62(10):5049-5062.
PMID: 31050898
The first generation of CB positive allosteric modulators (e.g., ZCZ011) featured a 3-nitroalkyl-2-phenyl-indole structure. Although a small number of drugs include the nitro group, it is generally not regarded as...
8.
Khatib T, Marini P, Nunna S, Chisholm D, Whiting A, Redfern C, et al.
Cell Commun Signal
. 2019 May;
17(1):40.
PMID: 31046795
Retinoic acid (RA) is the active metabolite of vitamin A and essential for many physiological processes, particularly the induction of cell differentiation. In addition to regulating genomic transcriptional activity via...
9.
Wat J, Hawrylyshyn K, Baczyk D, Greig I, Kingdom J
Biol Reprod
. 2018 Jun;
99(5):1082-1090.
PMID: 29860275
Low molecular weight heparin (LMWH) is being investigated as a potential preventative therapy against preeclampsia. There is evidence suggesting that LMWH may prevent preeclampsia through anticoagulation-independent mechanisms. In this study,...
10.
Tyagi R, Maddirala A, Elfawal M, Fischer C, Bulman C, Rosa B, et al.
ACS Infect Dis
. 2018 May;
4(7):1130-1145.
PMID: 29718656
The enormous prevalence of infections caused by parasitic nematodes worldwide, coupled to the rapid emergence of their resistance to commonly used anthelmintic drugs, presents an urgent need for the discovery...