I Vranesic
Overview
Explore the profile of I Vranesic including associated specialties, affiliations and a list of published articles.
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16
Citations
634
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Recent Articles
1.
Maj M, Bruno V, Dragic Z, Yamamoto R, Battaglia G, Inderbitzin W, et al.
Neuropharmacology
. 2003 Oct;
45(7):895-906.
PMID: 14573382
Group-III metabotropic glutamate receptors (mGluR4, -6, -7, and -8) modulate neurotoxicity of excitatory amino acids and beta-amyloid-peptide (betaAP), as well as epileptic convulsions, most likely via presynaptic inhibition of glutamatergic...
2.
Kuhn R, Pagano A, Stoehr N, Vranesic I, Flor P, Lingenhohl K, et al.
Amino Acids
. 2002 Oct;
23(1-3):207-11.
PMID: 12373539
There is a need to identify subtype-specific ligands for mGlu receptors to elucidate the potential of these receptors for the treatment of nervous system disorders. To date, most mGlu receptor...
3.
Gasparini F, Floersheim P, Flor P, Heinrich M, Inderbitzin W, Ott D, et al.
Farmaco
. 2001 May;
56(1-2):95-9.
PMID: 11347975
We have investigated the mechanism of inhibition of the new group I mGluR antagonists CPCCOEt and MPEP and determined that both compounds have a non-competitive mode of inhibition. Furthermore using...
4.
Walker K, Bowes M, Panesar M, Davis A, Gentry C, Kesingland A, et al.
Neuropharmacology
. 2000 Nov;
40(1):1-9.
PMID: 11077065
The excitatory neurotransmitter, glutamate, is particularly important in the transmission of pain information in the nervous system through the activation of ionotropic and metabotropic glutamate receptors. A potent, subtype-selective antagonist...
5.
Pagano A, Ruegg D, Litschig S, Stoehr N, Stierlin C, Heinrich M, et al.
J Biol Chem
. 2000 Aug;
275(43):33750-8.
PMID: 10934211
We have investigated the mechanism of inhibition and site of action of the novel human metabotropic glutamate receptor 5 (hmGluR5) antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP), which is structurally unrelated to classical metabotropic...
6.
Amori L, Costantino G, Marinozzi M, Pellicciari R, Gasparini F, Flor P, et al.
Bioorg Med Chem Lett
. 2000 Jul;
10(13):1447-50.
PMID: 10888329
On the basis of a pharmacophore definition of mGlu4 agonists, the two novel semi-rigid derivatives 12 and 13 were designed and synthesized. The preliminary biological evaluation demonstrated that both compounds...
7.
Gasparini F, Lingenhohl K, Stoehr N, Flor P, Heinrich M, Vranesic I, et al.
Neuropharmacology
. 1999 Oct;
38(10):1493-503.
PMID: 10530811
In the present paper we describe 2-methyl-6-(phenylethynyl)-pyridine (MPEP) as a potent, selective and systemically active antagonist for the metabotropic glutamate receptor subtype 5 (mGlu5). At the human mGlu5a receptor expressed...
8.
Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor P, Vranesic I, et al.
Mol Pharmacol
. 1999 Mar;
55(3):453-61.
PMID: 10051528
Metabotropic glutamate receptors (mGluRs) are a family of G protein-coupled receptors characterized by a large, extracellular N-terminal domain comprising the glutamate-binding site. In the current study, we examined the pharmacological...
9.
Batchelor A, Vranesic I, Del Principe F, Garthwaite J, Knopfel T
Neuroreport
. 1996 Aug;
7(12):1949-52.
PMID: 8905700
Brief tetanic stimulation of parallel fibres can evoke a slow excitatory postsynaptic potential (EPSP) in cerebellar Purkinje cells that is mediated by metabotropic glutamate receptors (mGluRs). It is likely that...
10.
Signal transmission in the parallel fiber-Purkinje cell system visualized by high-resolution imaging
Vranesic I, Iijima T, Ichikawa M, Matsumoto G, Knopfel T
Proc Natl Acad Sci U S A
. 1994 Dec;
91(26):13014-7.
PMID: 7809165
We investigated the synaptic transmission in the parallel fiber-Purkinje cell system at high spatio-temporal resolution by using voltage-sensitive dyes and an imaging system. In rat cerebellar slices, cut in the...