I E KARL
Overview
Explore the profile of I E KARL including associated specialties, affiliations and a list of published articles.
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Articles
95
Citations
2670
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Recent Articles
1.
Cobb J, Buchman T, KARL I, Hotchkiss R
Surg Infect (Larchmt)
. 2003 Feb;
1(3):207-13; discussion 214-5.
PMID: 12594891
Injury will equal or surpass communicable disease in the year 2020 as the number one cause of lost disability-adjusted life-years worldwide. The major cause of "late death" after trauma is...
2.
Hotchkiss R, Dunne W, Swanson P, Davis C, Tinsley K, Chang K, et al.
Science
. 2001 Dec;
294(5548):1783.
PMID: 11729269
No abstract available.
3.
Grayson M, Chaplin D, KARL I, Hotchkiss R
J Immunol Methods
. 2001 Aug;
256(1-2):55-63.
PMID: 11516755
Intravital microscopy has provided many insights into cellular interactions in various secondary lymphoid tissues. Because this technique allows for the visualization of cellular movement in real-time, it has been very...
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Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
Hotchkiss R, Tinsley K, Swanson P, Schmieg Jr R, Hui J, Chang K, et al.
J Immunol
. 2001 May;
166(11):6952-63.
PMID: 11359857
Patients with sepsis have impaired host defenses that contribute to the lethality of the disorder. Recent work implicates lymphocyte apoptosis as a potential factor in the immunosuppression of sepsis. If...
7.
Hotchkiss R, Chang K, Swanson P, Tinsley K, Hui J, Klender P, et al.
Nat Immunol
. 2001 Mar;
1(6):496-501.
PMID: 11101871
Sepsis induces lymphocyte apoptosis and prevention of lymphocyte death may improve the chances of surviving this disorder. We compared the efficacy of a selective caspase-3 inhibitor to a polycaspase inhibitor...
8.
Cobb J, Brownstein B, Watson M, Shannon W, Laramie J, Qiu Y, et al.
Shock
. 2001 Mar;
15(3):165-70.
PMID: 11236897
The traditional approach to the study of biology employs small-scale experimentation that results in the description of a molecular sequence of known function or relevance. In the era of the...
9.
Jacob A, Hotchkiss R, Swanson P, Tinsley K, KARL I, Buchman T
Shock
. 2000 Oct;
14(4):460-4.
PMID: 11049110
To determine whether iron-laden tissue subsequently stimulated to produce the stress ("heat shock") response-sustained injury, hindlimbs of male ND4 mice were injected with iron salts, hemin, or hemoglobin. The stress...
10.
Hotchkiss R, Schmieg Jr R, Swanson P, Freeman B, Tinsley K, Cobb J, et al.
Crit Care Med
. 2000 Sep;
28(9):3207-17.
PMID: 11008984
Objective: Apoptosis is a cellular suicide program that can be activated by cell injury or stress. Although a number of laboratory studies have shown that ischemia/reperfusion injury can induce apoptosis,...