K W Tinsley
Overview
Explore the profile of K W Tinsley including associated specialties, affiliations and a list of published articles.
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11
Citations
1386
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Recent Articles
1.
Hotchkiss R, Dunne W, Swanson P, Davis C, Tinsley K, Chang K, et al.
Science
. 2001 Dec;
294(5548):1783.
PMID: 11729269
No abstract available.
2.
Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
Hotchkiss R, Tinsley K, Swanson P, Schmieg Jr R, Hui J, Chang K, et al.
J Immunol
. 2001 May;
166(11):6952-63.
PMID: 11359857
Patients with sepsis have impaired host defenses that contribute to the lethality of the disorder. Recent work implicates lymphocyte apoptosis as a potential factor in the immunosuppression of sepsis. If...
3.
Hotchkiss R, Chang K, Swanson P, Tinsley K, Hui J, Klender P, et al.
Nat Immunol
. 2001 Mar;
1(6):496-501.
PMID: 11101871
Sepsis induces lymphocyte apoptosis and prevention of lymphocyte death may improve the chances of surviving this disorder. We compared the efficacy of a selective caspase-3 inhibitor to a polycaspase inhibitor...
4.
Jacob A, Hotchkiss R, Swanson P, Tinsley K, KARL I, Buchman T
Shock
. 2000 Oct;
14(4):460-4.
PMID: 11049110
To determine whether iron-laden tissue subsequently stimulated to produce the stress ("heat shock") response-sustained injury, hindlimbs of male ND4 mice were injected with iron salts, hemin, or hemoglobin. The stress...
5.
Hotchkiss R, Schmieg Jr R, Swanson P, Freeman B, Tinsley K, Cobb J, et al.
Crit Care Med
. 2000 Sep;
28(9):3207-17.
PMID: 11008984
Objective: Apoptosis is a cellular suicide program that can be activated by cell injury or stress. Although a number of laboratory studies have shown that ischemia/reperfusion injury can induce apoptosis,...
6.
Schmieg Jr R, Tinsley K, Swanson P, KARL I, Aft R, Buchman T, et al.
J Trauma
. 2000 Sep;
49(3):542-6.
PMID: 11003334
No abstract available.
7.
Hotchkiss R, Tinsley K, Hui J, Chang K, Swanson P, Drewry A, et al.
J Immunol
. 2000 Mar;
164(7):3675-80.
PMID: 10725725
Sepsis induces extensive apoptosis of lymphocytes, which may be responsible for the profound immune suppression of the disorder. Two potential pathways of sepsis-induced lymphocyte apoptosis, Fas and p53, were investigated....
8.
Tinsley K, Cheng S, Buchman T, Chang K, Hui J, Swanson P, et al.
Shock
. 2000 Jan;
13(1):1-7.
PMID: 10638661
Sepsis induces extensive lymphocyte cell death that may contribute to immune depression and morbidity/mortality in the disorder. bcl-2 is a member of a new class of oncogenes that prevents cell...
9.
Hotchkiss R, Tinsley K, Swanson P, Chang K, Cobb J, Buchman T, et al.
Proc Natl Acad Sci U S A
. 1999 Dec;
96(25):14541-6.
PMID: 10588741
Sepsis induces extensive lymphocyte apoptosis, a process which may be beneficial to host survival by down-regulating the inflammatory response or, alternatively, harmful by impairing host defenses. To determine the beneficial...
10.
Hotchkiss R, Swanson P, Freeman B, Tinsley K, Cobb J, Matuschak G, et al.
Crit Care Med
. 1999 Aug;
27(7):1230-51.
PMID: 10446814
Objectives: The purpose of this study was to determine whether apoptosis is a major mechanism of cell death in patients with sepsis. The activities of caspase-3 and the antiapoptotic protein,...