I D Dukes
Overview
Explore the profile of I D Dukes including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
646
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Recent Articles
1.
Dukes I, Sreenan S, Roe M, Levisetti M, Zhou Y, Ostrega D, et al.
J Biol Chem
. 1998 Sep;
273(38):24457-64.
PMID: 9733737
Mutations in the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene cause maturity onset diabetes of the young type 3, a form of type 2 diabetes mellitus. In mice lacking the HNF-1alpha gene,...
2.
Roe M, Worley 3rd J, Qian F, Tamarina N, Mittal A, Dralyuk F, et al.
J Biol Chem
. 1998 May;
273(17):10402-10.
PMID: 9553098
Although stimulation of insulin secretion by glucose is regulated by coupled oscillations of membrane potential and intracellular Ca2+ ([Ca2+]i), the membrane events regulating these oscillations are incompletely understood. In the...
3.
Kalman K, Nguyen A, Dukes I, Chandy G, Hustad C, Copeland N, et al.
J Biol Chem
. 1998 Apr;
273(10):5851-7.
PMID: 9488722
We report the isolation of a novel mouse voltage-gated Shaker-related K+ channel gene, Kv1.7 (Kcna7/KCNA7). Unlike other known Kv1 family genes that have intronless coding regions, the protein-coding region of...
4.
Roe M, Worley 3rd J, Mittal A, Kuznetsov A, Dasgupta S, Mertz R, et al.
J Biol Chem
. 1996 Dec;
271(50):32241-6.
PMID: 8943282
Voltage-dependent delayed rectifier K+ channels regulate aspects of both stimulus-secretion and excitation-contraction coupling, but assigning specific roles to these channels has proved problematic. Using transgenically derived insulinoma cells (betaTC3-neo) and...
5.
Dukes I, Philipson L
Diabetes
. 1996 Jul;
45(7):845-53.
PMID: 8666132
K+ channels play a key role in cellular physiology by regulating the efflux of K+ ions. They are the most diverse group of ion channel proteins; more than 30 K+...
6.
Mertz R, Worley J, Spencer B, Johnson J, Dukes I
J Biol Chem
. 1996 Mar;
271(9):4838-45.
PMID: 8617753
The energy requirements of most cells supplied with glucose are fulfilled by glycolytic and oxidative metabolism, yielding ATP. In pancreatic beta-cells, a rise in cytosolic ATP is also a critical...
7.
Roe M, Worley 3rd J, Tokuyama Y, Philipson L, Sturis J, Tang J, et al.
Am J Physiol
. 1996 Jan;
270(1 Pt 1):E133-40.
PMID: 8772485
Development of non-insulin-dependent diabetes mellitus (NIDDM) is associated with defects in glucose-stimulated insulin secretion. We have investigated Zucker diabetic fatty rats (ZDF), an animal model of NIDDM, and found that,...
8.
Roe M, Spencer B, Lancaster M, Mertz R, Worley 3rd J, Dukes I
Diabetologia
. 1995 Jul;
38(7):876-9.
PMID: 7556996
No abstract available.
9.
Worley 3rd J, McIntyre M, Spencer B, Dukes I
J Biol Chem
. 1994 Dec;
269(51):32055-8.
PMID: 7798198
Glucose stimulation of beta-cell insulin secretion is initiated by membrane depolarization coupled with an elevation in intracellular Ca2+ concentration ([Ca2+]i). Both depolarization-dependent Ca2+ entry and intracellular Ca2+ store release contribute...
10.
Philipson L, Rosenberg M, Kuznetsov A, Lancaster M, Worley 3rd J, Roe M, et al.
J Biol Chem
. 1994 Nov;
269(45):27787-90.
PMID: 7961701
Glucose stimulation of pancreatic beta-cell insulin secretion is closely coupled to alterations in ion channel conductances and intracellular Ca2+ ([Ca2+]i). To further examine this relationship after augmentation of voltage-dependent K+...