Hyun-Soon Geisler
Overview
Explore the profile of Hyun-Soon Geisler including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
451
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0
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Recent Articles
1.
Singer W, Manthey M, Panford-Walsh R, Matt L, Geisler H, Passeri E, et al.
Front Mol Neurosci
. 2018 Oct;
11:325.
PMID: 30319348
exon-IV and exon-VI transcripts are driven by neuronal activity and are involved in pathologies related to sleep, fear or memory disorders. However, how their differential transcription translates activity changes into...
2.
Matt L, Eckert P, Panford-Walsh R, Geisler H, Bausch A, Manthey M, et al.
Front Mol Neurosci
. 2018 Aug;
11:260.
PMID: 30127717
Activity-dependent BDNF (brain-derived neurotrophic factor) expression is hypothesized to be a cue for the context-specificity of memory formation. So far, activity-dependent BDNF cannot be explicitly monitored independently of basal BDNF...
3.
Mohrle D, Reimann K, Wolter S, Wolters M, Varakina K, Mergia E, et al.
Mol Pharmacol
. 2017 Sep;
92(4):375-388.
PMID: 28874607
Nitric oxide (NO) activates the NO-sensitive soluble guanylate cyclase (NO-GC, sGC) and triggers intracellular signaling pathways involving cGMP. For survival of cochlear hair cells and preservation of hearing, NO-mediated cascades...
4.
Singer W, Geisler H, Panford-Walsh R, Knipper M
Methods Mol Biol
. 2016 Jun;
1427:263-76.
PMID: 27259932
In sensory systems, a balanced excitatory and inhibitory circuit along the ascending pathway is not only important for the establishment of topographically ordered connections from the periphery to the cortex...
5.
Chumak T, Ruttiger L, Lee S, Campanelli D, Zuccotti A, Singer W, et al.
Mol Neurobiol
. 2015 Oct;
53(8):5607-27.
PMID: 26476841
For all sensory organs, the establishment of spatial and temporal cortical resolution is assumed to be initiated by the first sensory experience and a BDNF-dependent increase in intracortical inhibition. To...
6.
Zuccotti A, Lee S, Campanelli D, Singer W, Satheesh S, Patriarchi T, et al.
Front Mol Neurosci
. 2013 Aug;
6:20.
PMID: 23950737
Voltage-gated L-type Ca(2+) channels (L-VGCCs) like CaV1.2 are assumed to play a crucial role for controlling release of trophic peptides including brain-derived neurotrophic factor (BDNF). In the inner ear of...
7.
Singer W, Geisler H, Knipper M
Methods Mol Biol
. 2013 May;
1020:223-33.
PMID: 23709037
We recently demonstrated that an increase of guanosine 3',5'-cyclic monophosphate (cGMP) signaling could protect the inner ear from noise-induced hair cell damage. Noise exposure not only damages hair cells but...
8.
Singer W, Zuccotti A, Jaumann M, Lee S, Panford-Walsh R, Xiong H, et al.
Mol Neurobiol
. 2012 Nov;
47(1):261-79.
PMID: 23154938
Increasing evidence shows that hearing loss is a risk factor for tinnitus and hyperacusis. Although both often coincide, a causal relationship between tinnitus and hyperacusis has not been shown. Currently,...
9.
Zuccotti A, Kuhn S, Johnson S, Franz C, Singer W, Hecker D, et al.
J Neurosci
. 2012 Jun;
32(25):8545-53.
PMID: 22723694
The precision of sound information transmitted to the brain depends on the transfer characteristics of the inner hair cell (IHC) ribbon synapse and its multiple contacting auditory fibers. We found...
10.
Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, et al.
Nat Med
. 2012 Jan;
18(2):252-9.
PMID: 22270721
Noise-induced hearing loss (NIHL) is a global health hazard with considerable pathophysiological and social consequences that has no effective treatment. In the heart, lung and other organs, cyclic guanosine monophosphate...