Hugo Poirier
Overview
Explore the profile of Hugo Poirier including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
105
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Recent Articles
1.
Bubenik M, Mader P, Mochirian P, Vallee F, Clark J, Truchon J, et al.
J Med Chem
. 2022 Sep;
65(19):13198-13215.
PMID: 36126059
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead...
2.
Rioux N, Bellavance E, Poirier H, Dupuis M, Garneau M, Ribadeneira M, et al.
J Pharmacol Toxicol Methods
. 2013 Mar;
68(3):346-8.
PMID: 23518065
Introduction: Biliary excretion can modulate the pharmacokinetic profile of drug candidates, and may represent a liability for drug-drug interactions. This study proposes a strategy to reduce biliary clearance using the...
3.
Colombo F, Poirier H, Rioux N, Montecillo M, Duan J, Ribadeneira M
Xenobiotica
. 2013 Feb;
43(10):915-9.
PMID: 23402371
1. Prediction of biliary excretion is a challenge due to the lack of in vitro assays. Our laboratory previously demonstrated a highly significant correlation between in vitro IC50 values against...
4.
Coelho-Souza S, Guimaraes J, Miranda M, Poirier H, Mauro J, Lucotte M, et al.
Sci Total Environ
. 2011 May;
409(14):2746-53.
PMID: 21536317
Methylmercury (MeHg) increases mercury (Hg) toxicity and is biomagnified in the trophic chain contaminating riverine Amazon populations. Freshwater macrophyte roots are a main site of Hg methylation in different Brazilian...
5.
Wu T, Juteau H, Ducharme Y, Friesen R, Guiral S, Dufresne L, et al.
Bioorg Med Chem Lett
. 2010 Oct;
20(23):6978-82.
PMID: 20965723
Microsomal prostaglandin E(2) synthase (mPGES-1) represents a potential target for novel analgesic and anti-inflammatory agents. High-throughput screening identified several leads of mPGES-1 inhibitors which were further optimized for potency and...
6.
Houghton T, Tanaka K, Kang T, Dietrich E, Lafontaine Y, Delorme D, et al.
J Med Chem
. 2008 Oct;
51(21):6955-69.
PMID: 18834106
Osteomyelitis is an infection located in bone and a notoriously difficult disease to manage, requiring frequent and heavy doses of systemically administered antibiotics. Targeting antibiotics to the bone after systemic...
7.
Tanaka K, Houghton T, Kang T, Dietrich E, Delorme D, Ferreira S, et al.
Bioorg Med Chem
. 2008 Sep;
16(20):9217-29.
PMID: 18815051
Osteomyelitis is a difficult to treat bacterial infection of the bone. Delivering antibacterial agents to the bone may overcome the difficulties in treating this illness by effectively concentrating the antibiotic...
8.
Clark P, Rowland S, Denis D, Mathieu M, Stocco R, Poirier H, et al.
J Pharmacol Exp Ther
. 2008 Feb;
325(2):425-34.
PMID: 18287210
Previous evidence has implicated E prostanoid receptor 4 (EP4) in mechanical hyperalgesia induced by subplantar inflammation. However, its role in chronic arthritis remains to be further defined because previous attempts...
9.
Rose Y, Ciblat S, Reddy R, Belley A, Dietrich E, LeHoux D, et al.
Bioorg Med Chem Lett
. 2005 Nov;
16(4):891-6.
PMID: 16298129
The preparation and biological evaluation of 5-substituted-6-hydroxy-2-(anilino)pyrimidinones as a new class of DNA polymerase IIIC inhibitors, required for the replication of chromosomal DNA in Gram-positive bacteria, are described. These new...
10.
Poirier H, Labrecque J, Deschenes J, deLean A
Biochem J
. 2002 Feb;
362(Pt 1):231-7.
PMID: 11829760
The microbial polysaccharide HS-142-1 has been documented as an antagonist of natriuretic peptides. It inhibits activation and peptide binding to both guanylate receptors natriuretic peptide receptor (NPR)-A and NPR-B, but...