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Hua-Li Qin

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Articles 112
Citations 993
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Recent Articles
1.
Shu D, Fayad E, Abu Ali O, Qin H
J Org Chem . 2024 Nov; 89(22):16969-16974. PMID: 39482943
A new sulfonyl fluoride reagent 1-bromobut-3-ene-1,3-disulfonyl difluoride (BEDF) was developed. This unique reagent possesses two clickable functionalities to be used for both azide-alkyne cycloaddition click and SuFEx click reactions. This...
2.
Zheng S, Fayad E, Alshaye N, Qin H
J Org Chem . 2024 Sep; 89(19):14564-14570. PMID: 39315771
Herein, we developed a practical method for synthesizing a class of novel and highly valuable indolyl vinyl sulfonyl fluorides. This protocol has carved out a path for constructing a broad...
3.
Liu M, Fayad E, Abu Ali O, Tao X, Qin H
J Org Chem . 2024 Aug; 89(18):13709-13718. PMID: 39151070
A practical copper-catalyzed process for the synthesis of the β-arylethenesulfonyl fluorides is described. A series of α-bromo arylethyl sulfonyl fluorides was prepared via Meerwein reaction from arenediazonium tetrafluoroborates and ethenesulfonyl...
4.
Huang W, Fayad E, Abu Ali O, Qin H
Org Biomol Chem . 2024 Aug; 22(35):7117-7120. PMID: 39150283
A practical and efficient method for the C-3 site selective alkenylation of indoles was developed for constructing novel indole-functionalized vinyl sulfonyl fluorides and indolyl allylic sulfonyl fluorides. The reaction is...
5.
Wang X, Ajisafe M, Fayad E, Katouah H, Qin H
Org Biomol Chem . 2024 Jun; 22(26):5325-5332. PMID: 38874178
In this paper, the hydrogenation of aldehydes and ketones using the RANEY® nickel catalyst was successfully applied for the synthesis of alcohol compounds without additional column chromatographic purification. This synthetic...
6.
Leng J, Xu J, Li Y, Wang S, Qin H
RSC Adv . 2024 Mar; 14(11):7601-7608. PMID: 38440271
The construction of a class of novel triazole molecules containing sulfonyl fluoride functionalities was achieved through Cu-catalyzed click chemistry in good to excellent yields. The sulfonyl fluoride moieties were cleaved...
7.
Yin C, Qin R, Qin H
J Org Chem . 2024 Feb; 89(5):3618-3628. PMID: 38358945
A one-pot, sequential three-component reaction between salicylaldehyde, indole, and 2-bromoprop-2-ene-1-sulfonyl fluoride (BPESF) has been demonstrated for the synthesis of sulfonyl fluoride substituted 4-chromene derivatives in moderate to excellent yields (45%-94%)....
8.
Tang K, Li H, Wu C, Zhang S, Yang J, Tang W, et al.
J Enzyme Inhib Med Chem . 2023 Jul; 38(1):2237213. PMID: 37501629
Sulphur fluoride exchange (SuFEx) is a category of click chemistry that enables covalent linking of modular units through sulphur connective hubs. Here, we reported an efficient synthesis and screening method...
9.
Chen X, Qin H
Beilstein J Org Chem . 2023 Jun; 19:901-908. PMID: 37377774
A SOF-mediated ring-opening cross-coupling of cyclobutanone oxime derivatives with alkenes was developed for the construction of a range of δ-olefin-containing aliphatic nitriles with ()-configuration selectivity. This new method features wide...
10.
Shungube M, Hlophe A, Girdhari L, Sabe V, Peters B, Reddy N, et al.
RSC Adv . 2023 Jun; 13(28):18991-19001. PMID: 37362332
β-lactamases are enzymes that deactivate β-lactam antibiotics through a hydrolysis mechanism. There are two known types of β-lactamases: serine β-lactamases (SBLs) and metallo β-lactamases (MBLs). The two existing strategies to...