Hsu-Hsin Chen
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Explore the profile of Hsu-Hsin Chen including associated specialties, affiliations and a list of published articles.
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21
Citations
1135
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Recent Articles
1.
Wu B, Bennett H, Ye X, Sridhar A, Eidenschenk C, Everett C, et al.
Nat Commun
. 2024 Oct;
15(1):9146.
PMID: 39443484
Multiomic profiling of single cells by sequencing is a powerful technique for investigating cellular diversity. Existing droplet-based microfluidic methods produce many cell-free droplets, underutilizing bead barcodes and reagents. Combinatorial indexing...
2.
Orozco L, Owen L, Hofmann J, Stockwell A, Tao J, Haller S, et al.
Cell Genom
. 2023 Jun;
3(6):100302.
PMID: 37388919
Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200 million people worldwide. To identify genes that could be targeted for treatment, we created a molecular atlas at...
3.
Orozco L, Chen H, Cox C, Katschke Jr K, Rommel Arceo , Espiritu C, et al.
Cell Rep
. 2023 Mar;
42(3):112298.
PMID: 36952338
No abstract available.
4.
Liu C, Chen H
Methods Mol Biol
. 2022 Dec;
2560:333-346.
PMID: 36481908
Transcriptome profiling at single-cell resolution allows us to identify and assess functional cell types and cellular states, including those within degenerating ocular tissues in retinitis pigmentosa. The technology is particularly...
5.
den Hollander A, Mullins R, Orozco L, Voigt A, Chen H, Strunz T, et al.
Exp Eye Res
. 2022 Sep;
225:109248.
PMID: 36108770
Genomic studies in age-related macular degeneration (AMD) have identified genetic variants that account for the majority of AMD risk. An important next step is to understand the functional consequences and...
6.
Orozco L, Chen H, Cox C, Katschke Jr K, Rommel Arceo , Espiritu C, et al.
Cell Rep
. 2020 Jan;
30(4):1246-1259.e6.
PMID: 31995762
Age-related macular degeneration (AMD) is a leading cause of vision loss. To better understand disease pathogenesis and identify causal genes in GWAS loci for AMD risk, we present a comprehensive...
7.
Amamoto R, Zuccaro E, Curry N, Khurana S, Chen H, Cepko C, et al.
Nucleic Acids Res
. 2019 Nov;
48(1):e4.
PMID: 31728515
Thousands of frozen, archived tissue samples from the human central nervous system (CNS) are currently available in brain banks. As recent developments in RNA sequencing technologies are beginning to elucidate...
8.
Cicognola C, Brinkmalm G, Wahlgren J, Portelius E, Gobom J, Cullen N, et al.
Acta Neuropathol
. 2018 Dec;
137(2):279-296.
PMID: 30547227
Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer's disease (AD). Most of tau in CSF...
9.
Chen H, Liu P, Auger P, Lee S, Adolfsson O, Rey-Bellet L, et al.
Sci Rep
. 2018 Nov;
8(1):16725.
PMID: 30425303
The aggregation of intracellular tau protein is a major hallmark of Alzheimer's disease (AD). The extent and the stereotypical spread of tau pathology in the AD brain are correlated with...
10.