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Hsiao-Chi Chen

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Articles 16
Citations 152
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Recent Articles
1.
Kardian A, Sun H, Ippagunta S, Laboe N, Chen H, Emanus E, et al.
bioRxiv . 2024 Aug; PMID: 39211123
Highlights: 1. Specific chromatin modules accessible during brain development render distinct cell lineage programs at risk of transformation by pediatric fusion oncoproteins.2. Cross-species single cell ATAC and RNA (scMultiome) of...
2.
Chen H, He P, McDonald M, Williamson M, Varadharajan S, Lozzi B, et al.
Nature . 2024 Jul; 632(8026):903-910. PMID: 39085609
Bidirectional communication between tumours and neurons has emerged as a key facet of the tumour microenvironment that drives malignancy. Another hallmark feature of cancer is epigenomic dysregulation, in which alterations...
3.
Huang-Hobbs E, Cheng Y, Ko Y, Luna-Figueroa E, Lozzi B, Taylor K, et al.
Nature . 2023 Jun; 619(7971):844-850. PMID: 37380778
The tumour microenvironment plays an essential role in malignancy, and neurons have emerged as a key component of the tumour microenvironment that promotes tumourigenesis across a host of cancers. Recent...
4.
Sardar D, Cheng Y, Woo J, Choi D, Lee Z, Kwon W, et al.
Science . 2023 Jun; 380(6650):eade0027. PMID: 37319217
Neuronal activity drives alterations in gene expression within neurons, yet how it directs transcriptional and epigenomic changes in neighboring astrocytes in functioning circuits is unknown. We found that neuronal activity...
5.
Choi D, Armstrong G, Lozzi B, Vijayaraghavan P, Plon S, Wong T, et al.
Sci Adv . 2023 Apr; 9(17):eade2675. PMID: 37115922
Glioma is a rare brain tumor with a poor prognosis. Familial glioma is a subset of glioma with a strong genetic predisposition that accounts for approximately 5% of glioma cases....
6.
Cheng Y, Luna-Figueroa E, Woo J, Chen H, Lee Z, Harmanci A, et al.
Nature . 2023 Apr; 617(7960):369-376. PMID: 37100909
Communication between neurons and glia has an important role in establishing and maintaining higher-order brain function. Astrocytes are endowed with complex morphologies, placing their peripheral processes in close proximity to...
7.
Huang-Hobbs E, Cheng Y, Ko Y, Luna-Figueroa E, Lozzi B, Taylor K, et al.
bioRxiv . 2023 Mar; PMID: 36993539
The tumor microenvironment (TME) plays an essential role in malignancy and neurons have emerged as a key component of the TME that promotes tumorigenesis across a host of cancers. Recent...
8.
Cheng Y, Luna-Figueroa E, Woo J, Chen H, Lee Z, Harmanci A, et al.
bioRxiv . 2023 Mar; PMID: 36993256
Communication between neurons and glia plays an important role in establishing and maintaining higher order brain function. Astrocytes are endowed with complex morphologies which places their peripheral processes in close...
9.
Sardar D, Cheng Y, Woo J, Choi D, Lee Z, Kwon W, et al.
bioRxiv . 2023 Mar; PMID: 36909526
Neuronal activity drives global alterations in gene expression within neurons, yet how it directs transcriptional and epigenomic changes in neighboring astrocytes in functioning circuits is unknown. Here we show that...
10.
Sardar D, Chen H, Reyes A, Varadharajan S, Jain A, Mohila C, et al.
Proc Natl Acad Sci U S A . 2022 Jul; 119(29):e2202015119. PMID: 35858326
Epigenetic dysregulation is a universal feature of cancer that results in altered patterns of gene expression that drive malignancy. Brain tumors exhibit subtype-specific epigenetic alterations; however, the molecular mechanisms responsible...