Howard Schulman
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Explore the profile of Howard Schulman including associated specialties, affiliations and a list of published articles.
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47
Citations
3207
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Recent Articles
1.
Chen X, Cai Q, Zhou J, Pleasure S, Schulman H, Zhang M, et al.
Proc Natl Acad Sci U S A
. 2024 Jun;
121(26):e2402783121.
PMID: 38889145
Ca/calmodulin (CaM)-dependent kinase II (CaMKII) plays a critical role in long-term potentiation (LTP), a well-established model for learning and memory through the enhancement of synaptic transmission. Biochemical studies indicate that...
2.
Khan S, Molloy J, Puhl H, Schulman H, Vogel S
Biophys J
. 2024 Feb;
123(7):824-838.
PMID: 38414237
The binding of calcium/calmodulin (CAM) to calcium/calmodulin-dependent protein kinase II (CaMKII) initiates an ATP-driven cascade that triggers CaMKII autophosphorylation. The autophosphorylation in turn increases the CaMKII affinity for CAM. Here,...
3.
Rigter P, de Konink C, Dunn M, Proietti Onori M, Humberson J, Thomas M, et al.
Am J Hum Genet
. 2024 Jan;
111(2):364-382.
PMID: 38272033
The calcium/calmodulin-dependent protein kinase type 2 (CAMK2) family consists of four different isozymes, encoded by four different genes-CAMK2A, CAMK2B, CAMK2G, and CAMK2D-of which the first three have been associated recently...
4.
Chen X, Cai Q, Zhou J, Pleasure S, Schulman H, Zhang M, et al.
bioRxiv
. 2023 Sep;
PMID: 37662326
CaMKII plays a critical role in long-term potentiation (LTP), a well-established model for learning and memory through the enhancement of synaptic transmission. Biochemical studies indicate that CaMKII catalyzes a phosphotransferase...
5.
Tullis J, Larsen M, Rumian N, Freund R, Boxer E, Brown C, et al.
Nature
. 2023 Aug;
621(7977):146-153.
PMID: 37648853
Learning and memory are thought to require hippocampal long-term potentiation (LTP), and one of the few central dogmas of molecular neuroscience that has stood undisputed for more than three decades...
6.
Nicoll R, Schulman H
Physiol Rev
. 2023 Jun;
103(4):2877-2925.
PMID: 37290118
Ca/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP) were discovered within a decade of each other and have been inextricably intertwined ever since. However, like many marriages, it has...
7.
Dwyer B, Veenma D, Chang K, Schulman H, van Woerden G
Front Pharmacol
. 2022 May;
13:794008.
PMID: 35620293
Mutations in the genes encoding calcium/calmodulin dependent protein kinase II (CAMK2) isoforms cause a newly recognized neurodevelopmental disorder (ND), for which the full clinical spectrum has yet to be described....
8.
Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation
Bhattacharyya M, Lee Y, Muratcioglu S, Qiu B, Nyayapati P, Schulman H, et al.
Elife
. 2020 Mar;
9.
PMID: 32149607
The many variants of human Ca/calmodulin-dependent protein kinase II (CaMKII) differ in the lengths and sequences of disordered linkers connecting the kinase domains to the oligomeric hubs of the holoenzyme....
9.
Bayer K, Schulman H
Neuron
. 2019 Aug;
103(3):380-394.
PMID: 31394063
The Ca/calmodulin (CaM)-dependent protein kinase II (CaMKII) was touted as a memory molecule, even before its involvement in long-term potentiation (LTP) was shown. The enzyme has not disappointed, with subsequent...
10.
Pandini A, Schulman H, Khan S
PLoS Comput Biol
. 2019 Jun;
15(5):e1006796.
PMID: 31150387
The calcium calmodulin-dependent protein kinase II (CaMKII) is a dodecameric holoenzyme important for encoding memory. Its activation, triggered by binding of calcium-calmodulin, persists autonomously after calmodulin dissociation. One (receiver) kinase...