Howard H Yang
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Explore the profile of Howard H Yang including associated specialties, affiliations and a list of published articles.
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62
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1713
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Recent Articles
1.
Zhang H, Read A, Cataisson C, Yang H, Lee W, Turk B, et al.
Sci Signal
. 2024 May;
17(836):eadd5073.
PMID: 38743809
The Ras-mitogen-activated protein kinase (MAPK) pathway is a major target for cancer treatment. To better understand the genetic pathways that modulate cancer cell sensitivity to MAPK pathway inhibitors, we performed...
2.
Majocha M, Jackson D, Ha N, Amin R, Pangracova M, Ross C, et al.
PLoS Genet
. 2024 May;
20(5):e1011236.
PMID: 38722825
Patients with ER-negative breast cancer have the worst prognosis of all breast cancer subtypes, often experiencing rapid recurrence or progression to metastatic disease shortly after diagnosis. Given that metastasis is...
3.
Gruen C, Yang H, Sassano A, Wu E, Gopalan V, Marie K, et al.
bioRxiv
. 2023 Jun;
PMID: 37333132
Intratumoral heterogeneity (ITH) can promote cancer progression and treatment failure, but the complexity of the regulatory programs and contextual factors involved complicates its study. To understand the specific contribution of...
4.
Park W, Gray J, Holewinski R, Andresson T, So J, Carmona-Rivera C, et al.
Nat Cancer
. 2023 Mar;
4(3):419-435.
PMID: 36973439
Most tumor cells undergo apoptosis in circulation and at the metastatic organ sites due to host immune surveillance and a hostile microenvironment. It remains to be elucidated whether dying tumor...
5.
Hu N, Wang C, Zhang T, Su H, Liu H, Yang H, et al.
Cancers (Basel)
. 2022 Oct;
14(20).
PMID: 36291785
Background: Human Cub and Sushi Multiple Domains 1 (CSMD1) is a novel candidate tumor-suppressor gene that codes for multiple domains, including complement regulatory and adhesion proteins, and has recently been...
6.
Khan I, Gril B, Hoshino A, Yang H, Lee M, Difilippantonio S, et al.
Clin Exp Metastasis
. 2022 Aug;
39(5):815-831.
PMID: 35939247
Tumor-derived exosomes have documented roles in accelerating the initiation and outgrowth of metastases, as well as in therapy resistance. Little information supports the converse, that exosomes or similar vesicles can...
7.
Al Khamici H, Sanchez V, Yan H, Cataisson C, Michalowski A, Yang H, et al.
J Biol Chem
. 2022 Jul;
298(9):102275.
PMID: 35863434
The chloride intracellular channel-4 (CLIC4) is one of the six highly conserved proteins in the CLIC family that share high structural homology with GST-omega in the GST superfamily. While CLIC4...
8.
So J, Yang H, Park W, Skrypek N, Ishii H, Chen J, et al.
Mol Cancer Res
. 2022 Jul;
20(11):1674-1685.
PMID: 35857355
Implications: Our findings of transcriptome changes mediated by DNMT3B provide new mechanistic insight for intratumor heterogeneity and chemoresistance, and therapeutic targeting of DNMT3B in combination with chemotherapy offer additional treatment...
9.
Sanchez V, Yang H, Craig-Lucas A, Dubois W, Carofino B, Lack J, et al.
PLoS Genet
. 2022 Jun;
18(6):e1010271.
PMID: 35727842
The TGF-β-regulated Chloride Intracellular Channel 4 (CLIC4) is an essential participant in the formation of breast cancer stroma. Here, we used data available from the TCGA and METABRIC datasets to...
10.
Yang H, Liu H, Hu N, Su H, Wang C, Giffen C, et al.
Cancers (Basel)
. 2022 Apr;
14(7).
PMID: 35406404
We integrated ESCC expression and GWAS genotyping, to investigate eQTL and somatic DNA segment alterations, including somatic copy number alteration, allelic imbalance (AI), and loss of heterozygosity (LOH) in ESCC....