Howard C Towle
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Explore the profile of Howard C Towle including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Chambers K, Chen Z, Lai L, Leone T, Towle H, Kralli A, et al.
Mol Metab
. 2013 Sep;
2(3):194-204.
PMID: 24049734
Peroxisome proliferator-activated receptorγ coactivators (PGC-1α and PGC-1β) play important roles in the transcriptional regulation of intermediary metabolism. To evaluate the effects of overexpressing PGC-1α or PGC-1β at physiologic levels in...
2.
Petrie J, Al-Oanzi Z, Arden C, Tudhope S, Mann J, Kieswich J, et al.
Mol Cell Biol
. 2012 Dec;
33(4):725-38.
PMID: 23207906
In the liver, a high glucose concentration activates transcription of genes encoding glucose 6-phosphatase and enzymes for glycolysis and lipogenesis by elevation in phosphorylated intermediates and recruitment of the transcription...
3.
Hanse E, Mashek D, Becker J, Solmonson A, Mullany L, Mashek M, et al.
Cell Cycle
. 2012 Jul;
11(14):2681-90.
PMID: 22751438
Following acute hepatic injury, the metabolic capacity of the liver is altered during the process of compensatory hepatocyte proliferation by undefined mechanisms. In this study, we examined the regulation of...
4.
Arden C, Tudhope S, Petrie J, Al-Oanzi Z, Cullen K, Lange A, et al.
Biochem J
. 2012 Jan;
443(1):111-23.
PMID: 22214556
Glucose metabolism in the liver activates the transcription of various genes encoding enzymes of glycolysis and lipogenesis and also G6pc (glucose-6-phosphatase). Allosteric mechanisms involving glucose 6-phosphate or xylulose 5-phosphate and...
5.
Arden C, Petrie J, Tudhope S, Al-Oanzi Z, Claydon A, Beynon R, et al.
Diabetes
. 2011 Oct;
60(12):3110-20.
PMID: 22013014
Objective: The induction of hepatic glucose 6-phosphatase (G6pc) by glucose presents a paradox of glucose-induced glucose intolerance. We tested whether glucose regulation of liver gene expression is geared toward intracellular...
6.
Pashkov V, Huang J, Parameswara V, Kedzierski W, Kurrasch D, Tall G, et al.
J Biol Chem
. 2011 Mar;
286(17):15116-25.
PMID: 21357625
G protein-coupled receptor (GPCR) pathways control glucose and fatty acid metabolism and the onset of obesity and diabetes. Regulators of G protein signaling (RGS) are GTPase-activating proteins (GAPs) for G(i)...
7.
Davies M, OCallaghan B, Towle H
Am J Physiol Endocrinol Metab
. 2010 Aug;
299(4):E665-74.
PMID: 20682844
Carbohydrate response element-binding protein (ChREBP) is a glucose-dependent transcription factor that stimulates the expression of glycolytic and lipogenic genes in mammals. Glucose regulation of ChREBP has been mapped to its...
8.
Aipoalani D, OCallaghan B, Mashek D, Mariash C, Towle H
Endocrinology
. 2010 Mar;
151(5):2071-7.
PMID: 20233797
The Spot 14 (S14; Thrsp) gene has been implicated in supporting regulated lipogenesis in mammals. S14 gene expression in liver is controlled by a wide variety of hormones and dietary...
9.
Davies M, OCallaghan B, Towle H
J Biol Chem
. 2008 Jul;
283(35):24029-38.
PMID: 18591247
Carbohydrate response element-binding protein (ChREBP) is a glucose-responsive transcription factor that activates genes involved in de novo lipogenesis in mammals. The current model for glucose activation of ChREBP proposes that...
10.
Tsatsos N, Augustin L, Anderson G, Towle H, Mariash C
Endocrinology
. 2008 Jun;
149(10):5155-61.
PMID: 18556348
The Spot 14 (S14) gene is rapidly up-regulated by signals that induce lipogenesis such as enhanced glucose metabolism and thyroid hormone administration. Previous studies in S14 null mice show that...