Howard C Towle
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Explore the profile of Howard C Towle including associated specialties, affiliations and a list of published articles.
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20
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Recent Articles
11.
Tsatsos N, Davies M, OCallaghan B, Towle H
Biochem J
. 2008 Jan;
411(2):261-70.
PMID: 18215143
In the liver, induction of genes encoding enzymes involved in de novo lipogenesis occurs in response to increased glucose metabolism. ChREBP (carbohydrate-response-element-binding protein) is a basic helix-loop-helix/leucine zipper transcription factor...
12.
Towle H
Cell Metab
. 2007 Feb;
5(2):85-7.
PMID: 17276350
GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo...
13.
Ma L, Sham Y, Walters K, Towle H
Nucleic Acids Res
. 2006 Dec;
35(1):35-44.
PMID: 17148476
The carbohydrate response element (ChoRE) is a cis-acting sequence found in the promoters of genes induced transcriptionally by glucose. The ChoRE is composed of two E box-like motifs that are...
14.
Ma L, Robinson L, Towle H
J Biol Chem
. 2006 Aug;
281(39):28721-30.
PMID: 16885160
In mammals, glucose-regulated gene expression has been best characterized in the liver, where increased glucose metabolism induces transcription of genes encoding enzymes involved in de novo lipogenesis. ChREBP and Mlx...
15.
Tsatsos N, Towle H
Biochem Biophys Res Commun
. 2005 Dec;
340(2):449-56.
PMID: 16375857
Carbohydrate response element binding protein (ChREBP) is a transcription factor that mediates glucose-responsive changes in gene expression in hepatocytes. In the current model for glucose regulation, inhibition of ChREBP in...
16.
Towle H
Trends Endocrinol Metab
. 2005 Nov;
16(10):489-94.
PMID: 16269245
Glucose has essential metabolic roles as both a fuel for energy and a substrate for the biosynthesis of cell components. Because of its central importance, many cells have evolved mechanisms...
17.
Ma L, Tsatsos N, Towle H
J Biol Chem
. 2005 Jan;
280(12):12019-27.
PMID: 15664996
Enzymes required for de novo lipogenesis are induced in mammalian liver after a meal high in carbohydrates. In addition to insulin, increased glucose metabolism initiates an intracellular signaling pathway that...
18.
Stoeckman A, Ma L, Towle H
J Biol Chem
. 2004 Jan;
279(15):15662-9.
PMID: 14742444
The expression of genes encoding enzymes involved in de novo triglyceride synthesis (lipogenesis) is transcriptionally induced in the liver in response to increased glucose metabolism. The carbohydrate response element-binding protein...
19.
Wu C, Okar D, Stoeckman A, Peng L, Herrera A, Herrera J, et al.
Endocrinology
. 2003 Nov;
145(2):650-8.
PMID: 14617577
The effects of fructose-2,6-bisphosphate (F-2,6-P(2)) on hepatic glucokinase (GK) and glucose-6-phosphatase (G-6-Pase) gene expression were investigated in streptozotocin-treated mice, which exhibited undetectable levels of insulin. Hepatic F-2,6-P(2) levels were manipulated...
20.
Stoeckman A, Towle H
J Biol Chem
. 2002 May;
277(30):27029-35.
PMID: 12016216
A high carbohydrate diet up-regulates the transcription of enzymes of triglyceride biosynthesis (lipogenesis) in the mammalian liver. This treatment stimulates hepatic insulin signaling, leading to transcription of sterol regulatory element-binding...