Howard A Fine
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Explore the profile of Howard A Fine including associated specialties, affiliations and a list of published articles.
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164
Citations
9964
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Recent Articles
1.
Martinez-Meza S, Premeaux T, Cirigliano S, Friday C, Michael S, Mediouni S, et al.
J Neuroinflammation
. 2025 Mar;
22(1):66.
PMID: 40045391
Background: HIV-1-associated neurocognitive impairment (HIV-1-NCI) is marked by ongoing and chronic neuroinflammation with loss and decline in neuronal function even when antiretroviral drug therapy (ART) successfully suppresses viral replication. Microglia,...
2.
Breves S, Di Giammartino D, Nicholson J, Cirigliano S, Mahmood S, Lee U, et al.
bioRxiv
. 2025 Mar;
PMID: 40034649
Dysregulation of enhancer-promoter communication in the context of the three-dimensional (3D) nucleus is increasingly recognized as a potential driver of oncogenic programs. Here, we profiled the 3D enhancer-promoter networks of...
3.
Cirigliano S, Fine H
J Exp Med
. 2024 Dec;
222(1).
PMID: 39626263
Recent advances in cancer biology and therapeutics have underscored the importance of preclinical models in understanding and treating cancer. Nevertheless, current models often fail to capture the complexity and patient-specific...
4.
Pan S, Osborne J, Chiang G, Ramakrishna R, Tsiouris A, Fine H, et al.
Adv Radiat Oncol
. 2024 Sep;
9(9):101567.
PMID: 39253332
No abstract available.
5.
Kim J, Chang S, Haghdel A, Ramakrishna R, Pannullo S, Schwartz T, et al.
AJNR Am J Neuroradiol
. 2024 Apr;
45(6):773-780.
PMID: 38604734
Background And Purpose: WHO grade 3 meningiomas are rare and poorly understood and have a higher propensity for recurrence, metastasis, and worsened clinical outcomes compared with lower-grade meningiomas. The purpose...
6.
Giacobetti S, Fine H
Cancer Cell
. 2024 Apr;
42(5):741-743.
PMID: 38579726
In this issue of Cancer Cell, Spitzer and colleagues demonstrate the role of IDH inhibitors on IDHmutant gliomas in reducing proliferation and enhancing cell differentiation toward an astrocytic-like state, thus...
7.
Fine H
Cancer Discov
. 2024 Apr;
14(4):648-652.
PMID: 38571415
This commentary urges a paradigm shift in how we approach research and drug development for glioblastoma, reimagining it as an aberrant brain-like organ, distinct from other cancers, to inspire innovative...
8.
Furnari F, Anastasaki C, Bian S, Fine H, Koga T, Le L, et al.
Dis Model Mech
. 2024 Feb;
17(2).
PMID: 38353122
Nervous system tumors, particularly brain tumors, represent the most common tumors in children and one of the most lethal tumors in adults. Despite decades of research, there are few effective...
9.
Jeon H, Kim J, Cho H, Lee W, Nguyen D, Kim S, et al.
Cancer Cell
. 2023 Jul;
41(8):1480-1497.e9.
PMID: 37451272
Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM), but inevitably induces poorly understood global changes in GBM and its microenvironment (TME) that promote radio-resistance and recurrence. Through...
10.
Pine A, Cirigliano S, Singhania R, Nicholson J, da Silva B, Leslie C, et al.
Cancer Res
. 2023 Mar;
83(10):1581-1595.
PMID: 36877162
Significance: Single-cell analyses elucidate the chromatin landscape and transcriptional regulation of glioblastoma cellular states and identify a radial glia-like population, providing potential targets to disrupt cell states and improve therapeutic...