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» Authors » Hossam R Elgiushy

Hossam R Elgiushy

Explore the profile of Hossam R Elgiushy including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 3
Citations 8
Followers 0
Related Specialties
Biochemistry
Chemistry
Top 10 Co-Authors
Nageh A Abou-Taleb
Sherif F Hammad
Khaled A M Abouzid
Zeinab Hassan
Sameh H Mohamed
Heba Taha
Oleg G Chepurny
George Liapakis
Sotirios Kakabakos
Hussein Sawaf
Published In
Bioorg Chem
Bioorg Med Chem
Affiliations
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Recent Articles
1.
Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment
Elgiushy H, Mohamed S, Taha H, Sawaf H, Hassan Z, Abou-Taleb N, et al.
Bioorg Chem . 2022 Feb; 120:105646. PMID: 35134645
A new series of sixteen new 2-arylamino-5,7-disubstituted-N-aryl-pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives was designed and synthesized. The antitumor activities of the new compounds were initially screened through the developmental therapeutics program at NCI-USA 60...
2.
Synthesis, in vitro biological investigation, and molecular dynamics simulations of thiazolopyrimidine based compounds as corticotrophin releasing factor receptor-1 antagonists
Elgiushy H, Abou-Taleb N, Holz G, Chepurny O, Pirmettis I, Kakabakos S, et al.
Bioorg Chem . 2021 Jun; 114:105079. PMID: 34174633
Corticotrophin releasing factor receptor-1 (CRFR1) is a potential target for treatment of depression and anxiety through modifying stress response. A series of new thiazolo[4,5-d]pyrimidine derivatives were designed, prepared and biologically...
3.
An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties
Mohamed S, Elgiushy H, Taha H, Hammad S, Abou-Taleb N, Abouzid K, et al.
Bioorg Med Chem . 2020 Aug; 28(17):115633. PMID: 32773088
New thiazolo[4,5-d]pyrimidine analogues were synthesized and biologically assessed in-vitro for their antineoplastic activity. The growth inhibitory effects of these compounds were assessed through the National Cancer Institute-United States of America...