Khaled A M Abouzid
Overview
Explore the profile of Khaled A M Abouzid including associated specialties, affiliations and a list of published articles.
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Articles
84
Citations
590
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Recent Articles
1.
El-Nagar M, Shahin M, El-Behairy M, Taher E, El-Badawy M, Sharaky M, et al.
RSC Med Chem
. 2024 Sep;
PMID: 39246752
Cancer patients undergoing chemotherapy are highly susceptible to infections owing to their compromised immune system, which also promotes cancer progression through inflammation. Thus, this study aimed to develop novel chemotherapeutic...
2.
Jaballah M, Elleboudy N, Sharaky M, Abouzid K, Shahin M
Future Med Chem
. 2024 Aug;
16(13):1299-1311.
PMID: 39109431
Design and synthesis of pyrazole-based chemotherapeutic agents. A series of novel diphenyl pyrazole-chalcone derivatives were synthesized and assessed for their cytotoxic activities against 14 cancer cell lines and their antimicrobial...
3.
Oudah K, Najm M, Barghash R, Kutkat O, GabAllah M, Albohy A, et al.
BMC Chem
. 2024 Jul;
18(1):132.
PMID: 39014447
The search for new molecules targeting SARS-CoV-2 has been a priority since 2020. The continuous evolution of new mutants increases the need for more research in the area. One way...
4.
Mansour M, Hassan G, Serya R, Jaballah M, Abouzid K
Bioorg Chem
. 2024 Apr;
147:107332.
PMID: 38581966
Activin receptor‑like kinase-5 (ALK5) is an outstanding member of the transforming growth factor-β (TGF-β) family. (TGF-β) signaling pathway integrates pleiotropic proteins that regulate various cellular processes such as growth, proliferation,...
5.
Abdelrahman N, Al-Karmalawy A, Jaballah M, Yahya G, Sharaky M, Abouzid K
RSC Med Chem
. 2024 Mar;
15(3):981-997.
PMID: 38516606
Guided by the molecular hybridization principle, a novel series of 4-chloropyridazinoxyphenyl conjugates (3a-h, 4a-e, and 5) was designed and synthesized as proposed apoptotic inducers and PARP-1 inhibitors. The growth inhibition...
6.
Higazy S, Samir N, El-Khouly A, Giovannuzzi S, Begines P, Gaber H, et al.
Bioorg Chem
. 2024 Jan;
144:107089.
PMID: 38237393
Eighteen novel compounds harboring the privileged thienopyrimidine scaffold (5a-q, and 6a),were designed based on molecular hybridization strategy. These compounds were synthesized and tested for their inhibitory activity against four different...
7.
Saleh J, Abd El Hadi S, Ibrahim H, Elrazaz E, Abouzid K
BMC Chem
. 2023 Sep;
17(1):127.
PMID: 37759329
New thienopyrimidine derivatives were designed and synthesized as GSK-3β inhibitors based on the structure of active binding site of GSK-3β enzyme. In this study, compounds 6b and 6a were found...
8.
Shaban R, Samir N, Nissan Y, Abouzid K
RSC Adv
. 2023 Jun;
13(25):17074-17096.
PMID: 37293475
In continuation of our efforts to discover new structural chemotypes with significant chemotherapeutic activities, a novel series of pyrazolo[3,4-]pyrimidine-based compounds linked to a piperazine ring, bearing different aromatic moieties, through...
9.
Rana N, Aziz M, Serya R, Lasheen D, Samir N, Wuest F, et al.
ACS Bio Med Chem Au
. 2023 Apr;
3(1):51-61.
PMID: 37101605
Rapid cell division and reprogramming of energy metabolism are two crucial hallmarks of cancer cells. In humans, hexose trafficking into cancer cells is mainly mediated through a family of glucose...
10.
Refaey M, Fayed M, Kutkat O, Moatasim Y, Tolba N, Anis A, et al.
Arab J Chem
. 2023 Mar;
16(7):104813.
PMID: 36969951
The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has opened the door to potential threats of the respiratory system. The discovery of drugs from natural sources...