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George Liapakis

Explore the profile of George Liapakis including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 51
Citations 474
Followers 0
Related Specialties
Chemistry
Pharmacology
Biochemistry
Top 10 Co-Authors
Vlasios Karageorgos
Maria Venihaki
Katerina Spyridaki
Thomas Mavromoustakos
Minos-Timotheos Matsoukas
Hesham Fahmy
Andreas G Tzakos
George G Holz
Theodore Tselios
Andrew N Margioris
Published In
Eur J Med Chem
Curr Mol Pharmacol
J Biol Chem
Hormones (Athens)
Mol Pharmacol
Affiliations
Soon will be listed here.
Recent Articles
1.
Two GnRH-mitoxantrone Conjugates, Con-3 and Con-7, Target Endometrial Cancer Cells
Markatos C, Biniari G, Karageorgos V, Chepurny O, Venihaki M, Holz G, et al.
Curr Mol Pharmacol . 2025 Feb; PMID: 39902544
Introduction: Endometrial cancer is one of the most common gynecological malignancies. Endometrial cancer cells express the gonadotropin-releasing hormone (GnRH) and its receptor (GnRH-R). Among the various therapeutic approaches for the...
2.
Cytotoxic Activity of Novel GnRH Analogs Conjugated with Mitoxantrone in Ovarian Cancer Cells
Markatos C, Biniari G, Chepurny O, Karageorgos V, Tsakalakis N, Komontachakis G, et al.
Molecules . 2024 Sep; 29(17. PMID: 39274973
The gonadotropin-releasing hormone (GnRH) receptor (GnRH-R) is highly expressed in ovarian cancer cells (OCC), and it is an important molecular target for cancer therapeutics. To develop a new class of...
3.
Design, Synthesis, and Biological Evaluations of Novel Thiazolo[4,5-d]pyrimidine Corticotropin Releasing Factor (CRF) Receptor Antagonists as Potential Treatments for Stress Related Disorders and Congenital Adrenal Hyperplasia (CAH)
Islam M, Markatos C, Pirmettis I, Papadopoulos M, Karageorgos V, Liapakis G, et al.
Molecules . 2024 Aug; 29(15). PMID: 39125051
Corticotropin-releasing factor (CRF) is a key neuropeptide hormone that is secreted from the hypothalamus. It is the master hormone of the HPA axis, which orchestrates the physiological and behavioral responses...
4.
Corticotropin-releasing hormone deficiency results in impaired analgesic response during CFA-induced inflammation
Karagianni E, Rassouli O, Poulaki S, Dermitzaki E, Liapakis G, Margioris A, et al.
Hormones (Athens) . 2024 May; 23(3):535-545. PMID: 38740711
Purpose: Corticotropin-releasing hormone (CRH) plays an important role in relief of pain by releasing analgesia-associated molecules in several inflammatory states. During inflammation, peripheral CRH acts on cells of the immune...
5.
Structural and Functional Insights into CRF Peptides and Their Receptors
Matsoukas M, Panagiotopoulos V, Karageorgos V, Chrousos G, Venihaki M, Liapakis G
Biology (Basel) . 2024 Feb; 13(2). PMID: 38392338
Corticotropin-releasing factor or hormone (CRF or CRH) and the urocortins regulate a plethora of physiological functions and are involved in many pathophysiological processes. CRF and urocortins belong to the family...
6.
Rational Design, Synthesis and Binding Affinity Studies of Anthraquinone Derivatives Conjugated to Gonadotropin-Releasing Hormone (GnRH) Analogues towards Selective Immunosuppression of Hormone-Dependent Cancer
Biniari G, Markatos C, Nteli A, Tzoupis H, Simal C, Vlamis-Gardikas A, et al.
Int J Mol Sci . 2023 Oct; 24(20). PMID: 37894912
Gonadotropin-releasing hormone (GnRH) is pivotal in regulating human reproduction and fertility through its specific receptors. Among these, gonadotropin-releasing hormone receptor type I (GnRHR I), which is a member of the...
7.
Design, synthesis, structural optimization, SAR, in silico prediction of physicochemical properties and pharmacological evaluation of novel & potent thiazolo[4,5-d]pyrimidine corticotropin releasing factor (CRF) receptor antagonists
Islam M, Teleb M, Karageorgos V, Sakellaris S, Papadopoulos M, Pirmettis I, et al.
Eur J Pharm Sci . 2021 Dec; 169:106084. PMID: 34856350
Corticotropin-releasing factor (CRF) is a 41-amino-acid neuropeptide secreted from the hypothalamus and is the main regulator of the hypothalamus-pituitary-adrenocortical (HPA) axis. CRF is the master hormone which modulates physiological and...
8.
Analgesic and Anti-Inflammatory Effects of the Synthetic Neurosteroid Analogue BNN27 during CFA-Induced Hyperalgesia
Poulaki S, Rassouli O, Liapakis G, Gravanis A, Venihaki M
Biomedicines . 2021 Sep; 9(9). PMID: 34572370
Dehydroepiandrosterone (DHEA), an adrenal and neurosteroid hormone with strong neuroprotective and immunomodulatory properties, and ligand for all high-affinity neurotrophin tyrosine kinase receptors (Trk), also exerts important effects on hyperalgesia. Its...
9.
Synthesis, in vitro biological investigation, and molecular dynamics simulations of thiazolopyrimidine based compounds as corticotrophin releasing factor receptor-1 antagonists
Elgiushy H, Abou-Taleb N, Holz G, Chepurny O, Pirmettis I, Kakabakos S, et al.
Bioorg Chem . 2021 Jun; 114:105079. PMID: 34174633
Corticotrophin releasing factor receptor-1 (CRFR1) is a potential target for treatment of depression and anxiety through modifying stress response. A series of new thiazolo[4,5-d]pyrimidine derivatives were designed, prepared and biologically...
10.
Discovery of a stable tripeptide targeting the N-domain of CRF1 receptor
Liapakis G, Karageorgos V, Andreadelis I, Holz G, Dermitzaki E, Kordopati G, et al.
Amino Acids . 2020 Sep; 52(9):1337-1351. PMID: 32996057
The corticotropin-releasing factor (CRF) and its CRF1 receptor (CRFR) play a central role in the maintenance of homeostasis. Malfunctioning of the CRF/CRFR unit is associated with several disorders, such as...